Anemia and Optimal Transfusion Thresholds in Brain-Injured Patients: A Narrative Review of the Literature

被引：0

作者：

Ma, Kan ^{[1
]}

Bebawy, John F. ^{[2
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Dept Anesthesiol & Pain Med, 30 Bond St, Toronto, ON, Canada

[2] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol & Neurol Surg, Chicago, IL USA

来源：

ANESTHESIA AND ANALGESIA | 2024年 / 138卷 / 05期

关键词：

BLOOD-CELL TRANSFUSION; ANEURYSMAL SUBARACHNOID HEMORRHAGE; CEREBRAL OXYGEN DELIVERY; HEMOGLOBIN LEVELS; ISCHEMIC-STROKE; MORTALITY; ADMISSION; OUTCOMES; IMPACT; HEMATOCRIT;

D O I：

10.1213/ANE.0000000000006772

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Anemia is a highly prevalent condition that may compromise oxygen delivery to vital organs, especially among the critically ill. Although current evidence supports the adoption of a restrictive transfusion strategy and threshold among the nonbleeding critically ill patient, it remains unclear whether this practice should apply to the brain-injured patient, given the predisposition to cerebral ischemia in this patient population, in which even nonprofound anemia may exert a detrimental effect on clinical outcomes. The purpose of this review is to provide an overview of the pathophysiological changes related to impaired cerebral oxygenation in the brain-injured patient and to present the available evidence on the effect of anemia and varying transfusion thresholds on the clinical outcomes of patients with acute brain injury.

引用

页码：992 / 1002

页数：11

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