MODELS OF RELEASE OF ACTIVE COMPOUNDS FROM NANOSTRUCTURED MULTI-LAYERED MATERIALS

Controlled drug release is the transport of an active compound of biologically active agents with a defined time-concentration function. The release of these active compounds from materials is currently achieved by numerical models, based on simple kinetics of the first order, that are used to analyze experimental processes. In this contribution, we propose a model that enables us to design complex, multi-layered material and define the desired time-concentration function for the release. This approach enables us to tailor the material in such a way that each layer has an individual concentration of the active compound. The result of programming work in models provides instructions for the design of the materials, which are specifically suited to certain situations. The model corresponds to real material structures from nanostructured electrospun material, in which the layers are pasted together with continuous hydrogel layers (for example, collagen). The final version of the model will enable us to design the patches in the medicine where the release of antibiotics, healing or nutritional compounds will be programmed according to a certain time-release protocol. It is assumed that it will be possible to synchronize the controlled release of two or more compounds, each with different time protocols.