Ultrasound-Assisted Extraction of Phenolic Compounds from Celtuce (Lactuca sativa var. augustana) Leaves Using Natural Deep Eutectic Solvents (NADES): Process Optimization and Extraction Mechanism Research

被引:9
作者
Li, Shanshan [1 ]
Wang, Guangyu [1 ]
Zhao, Junjie [1 ]
Ou, Penghui [1 ]
Yao, Qingping [2 ]
Wang, Wei [1 ]
机构
[1] Shanghai Inst Technol, Sch Perfume & Aroma & Cosmet, Shanghai 201418, Peoples R China
[2] Shanghai Jiao Tong Univ, Inst Mechanobiol & Med Engn, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
基金
中国国家自然科学基金;
关键词
ultrasonic-assisted extraction; natural deep eutectic solvent; phenolic compounds; celtuce (Lactuca sativa var. augustana) leaves; molecular dynamics; BIOACTIVE COMPOUNDS; GREEN EXTRACTION; POLYPHENOLS; ANTIOXIDANT; FLAVONOIDS; EFFICIENCY; WATER; OIL;
D O I
10.3390/molecules29102385
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Natural deep eutectic solvents (NADESs), as emerging green solvents, can efficiently extract natural products from natural resources. However, studies on the extraction of phenolic compounds from celtuce (Lactuca sativa var. augustana) leaves (CLs) by NADESs are still lacking. This study screened the NADES L-proline-lactic acid (Pr-LA), combined it with ultrasound-assisted extraction (UAE) to extract phenolic compounds from CLs, and conducted a comparative study on the extraction effect with traditional extraction solvents. Both SEM and FT-IR confirmed that Pr-LA can enhance the degree of fragmentation of cell structures and improve the extraction rate of phenolic compounds. Molecular dynamics simulation results show that Pr-LA can improve the solubility of phenolic compounds and has stronger hydrogen bonds and van der Waals interactions with phenolic compounds. Single-factor and Box-Behnken experiments optimized the process parameters for the extraction of phenolic compounds from CLs. The second-order kinetic model describes the extraction process of phenolic compounds from CLs under optimal process parameters and provides theoretical guidance for actual industrial production. This study not only provides an efficient and green method for extracting phenolic compounds from CLs but also clarifies the mechanism of improved extraction efficiency, which provides a basis for research on the NADES extraction mechanism.
引用
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页数:20
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