Mesenchymal Stromal Cell-Based Products: Challenges and Clinical Therapeutic Options

被引：10

作者：

Mello, Debora B. ^{[1
]}

Mesquita, Fernanda Cristina Paccola ^{[2
]}

dos Santos, Danubia Silva ^{[3
,4
]}

Asensi, Karina Dutra ^{[4
,5
]}

Dias, Marlon Lemos ^{[5
]}

de Carvalho, Antonio Carlos Campos ^{[1
,4
,5
]}

Goldenberg, Regina Coeli dos Santos ^{[4
,5
]}

Kasai-Brunswick, Tais Hanae ^{[1
,4
,5
]}

机构：

[1] Univ Fed Rio de Janeiro, Natl Ctr Struct Biol & Bioimaging, CENABIO, BR-21941902 Rio De Janeiro, Brazil

[2] Texas Heart Inst, Regenerat Med Res Dept, Houston, TX 77030 USA

[3] INC, Ctr Cellular Technol, Natl Inst Cardiol, BR-22240002 Rio De Janeiro, Brazil

[4] Univ Fed Rio de Janeiro, Natl Inst Sci & Technol Regenerat Med, REGENERA, BR-21941902 Rio De Janeiro, Brazil

[5] Univ Fed Rio de Janeiro, Carlos Chagas Filho Inst Biophys, BR-21941902 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期

关键词：

mesenchymal stromal cell; advanced therapy medicinal products; regenerative medicine; PULP STEM-CELLS; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; DENTAL-PULP; IN-VITRO; ADIPOSE-TISSUE; INTERNATIONAL-SOCIETY; DECIDUOUS TEETH; PRECURSOR CELLS; TRANSPLANTATION;

D O I：

10.3390/ijms25116063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stromal cell (MSC)-based advanced therapy medicinal products (ATMPs) are being tried in a vast range of clinical applications. These cells can be isolated from different donor tissues by using several methods, or they can even be derived from induced pluripotent stem cells or embryonic stem cells. However, ATMP heterogeneity may impact product identity and potency, and, consequently, clinical trial outcomes. In this review, we discuss these topics and the need to establish minimal criteria regarding the manufacturing of MSCs so that these innovative therapeutics may be better positioned to contribute to the advancement of regenerative medicine.

引用

页数：23

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