Synthesis of tetralone and indanone derivatives via cascade reductive Friedel-Crafts alkylation/cyclization of keto acids/esters

被引：0

作者：

Yadav, Naveen ^{[1
]}

Mahato, Rina ^{[1
]}

Khan, Jabir ^{[1
]}

Jaiswal, Harshit ^{[1
]}

Hazra, Chinmoy Kumar ^{[1
]}

机构：

[1] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 69期

关键词：

Alkylation;

D O I：

10.1039/d4cc02754j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We disclose herein a metal-free cascade reductive Friedel-Crafts alkylation/cyclization of keto acids/esters for the synthesis of tetralones and indanones. Owing to the simple reaction conditions and setup, this protocol features broad substrate generality, facile scalability, and remarkable functional group tolerance, including the synthesis of bioactive molecule sertraline.

引用

页码：9274 / 9277

页数：4

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