Manufacturing and validation of small-diameter vascular grafts: A mini review

被引：7
作者：
Hernandez-Sanchez, Deyanira [1 ]
Comtois-Bona, Maxime [1 ]
Munoz, Marcelo [1 ]
Ruel, Marc [1 ,2 ,3 ]
Suuronen, Erik J. [1 ,3 ]
Alarcon, Emilio I. [1 ,4 ]
机构：
[1] Univ Ottawa Heart Inst, Div Cardiac Surg, BioEngn & Therapeut Solut BEaTS Res, 40 Ruskin St, Ottawa, ON K1Y4W7, Canada
[2] Univ Ottawa Heart Inst, Div Cardiac Surg, 40 Ruskin St, Ottawa, ON K1Y4W7, Canada
[3] Univ Ottawa, Dept Cellular & Mol Med, 451 Smyth Rd, Ottawa, ON K1H8M5, Canada
[4] Univ Ottawa, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
来源：
ISCIENCE | 2024年 / 27卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
ENGINEERED BLOOD-VESSELS; 3D PRINTING TECHNOLOGY; TISSUE CONSTRUCTS; ANIMAL-MODELS; MECHANICAL-PROPERTIES; ELASTOMERIC SCAFFOLD; ARTERIAL GRAFTS; BIOMATERIALS; PERFORMANCE; COLLAGEN;
D O I：
10.1016/j.isci.2024.109845
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The field of small-diameter vascular grafts remains a challenge for biomaterials scientists. While decades of research have brought us much closer to developing biomimetic materials for regenerating tissues and organs, the physiological challenges involved in manufacturing small conduits that can transport blood while not inducing an immune response or promoting blood clots continue to limit progress in this area. In this short review, we present some of the most recent methods and advancements made by researchers working in the field of small-diameter vascular grafts. We also discuss some of the most critical aspects biomaterials scientists should consider when developing lab-made small-diameter vascular grafts.
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页数：27
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