Translocator protein (18 kDa) positron emission tomography imaging as a biomarker of neuroinflammation in epilepsy

被引：2
作者：
Qin, Li [1 ]
Xiao, Ling [2 ]
Zhu, Haoyue [1 ]
Du, Yangsa [1 ]
Tang, Yongxiang [2 ]
Feng, Li [1 ,3 ,4 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Neurol, Changsha 410008, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Nucl Med, Changsha 410008, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Dept Neurol, Jiangxi Branch, Nanchang 330000, Jiangxi, Peoples R China
来源：
NEUROLOGICAL SCIENCES | 2024年 / 45卷 / 11期
基金：
中国国家自然科学基金;
关键词：
TSPO; PET; Epilepsy; Neuroinflammation; Microglia; SPONTANEOUS RECURRENT SEIZURES; MICROGLIAL ACTIVATION; BRAIN INFLAMMATION; BINDING-SITES; RAT MODEL; PET; TSPO; MINOCYCLINE; COMPLEX; MARKER;
D O I：
10.1007/s10072-024-07648-9
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Increasing evidence indicate that neuroinflammation triggered by glial cells plays a significant role in epileptogenesis. To this effect, the overexpression of translocator protein 18 kDa (TSPO) in activated microglia and astrocytes has been identified as an inflammatory biomarker in epilepsy. It is now possible to quantify neuroinflammation using non-invasive positron emission tomography (PET) imaging of TSPO. With the advancement of radiotracers, TSPO PET has become an innovative tool in elucidating the "neuroinflammatory machinery" of drug-resistant epilepsy. Furthermore, TSPO PET has demonstrated potential in detecting MRI-negative epileptogenic zones (EZ) and provided an innovative perspective in epileptic medical treatment. This manuscript presents a comprehensive exploration of the neuroinflammatory mechanisms of epilepsy, alongside a thorough review of TSPO PET studies conducted in clinical and preclinical settings. The primary objective is to deepen our understanding of epilepsy progression and to establish TSPO PET as an effective monitoring tool for treatment efficacy.
引用
收藏
页码：5201 / 5211
页数：11
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