Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology

被引：0

作者：

Wang, Yi ^{[1
]}

Yin, Li ^{[1
]}

Du, Yao-Yao ^{[1
]}

Liao, Hong-Mei ^{[1
]}

Li, Juan ^{[1
]}

Yao, Wen ^{[2
]}

Yuan, Xiao-Qiong ^{[3
]}

Guo, Qing-Chun ^{[1
]}

Deng, Tao -Ran ^{[1
]}

Guo, Na ^{[1
]}

Zhang, Min ^{[3
,4
]}

Zeng, Qiang ^{[3
,4
]}

Li, Chong ^{[5
]}

Li, Yu Feng ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China

[2] Gen Hosp Cent Theater Command, Wuhan, Hubei, Peoples R China

[3] Zhengzhou Univ, Affiliated Hosp 3, Reprod Ctr, Zhengzhou, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Sch Publ Hlth, Dept Environm Hlth, Shanghai, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2024年 / 108卷

基金：

中国国家自然科学基金;

关键词：

Assisted reproductive technology; Liver function; Mixture analysis; Phthalate; Bilirubin; Gamma-glutamyl transferase; GAMMA-GLUTAMYL-TRANSFERASE; HORMONE-BINDING GLOBULIN; OXIDATIVE STRESS; URINARY CONCENTRATIONS; METABOLITES; HEALTH; DISEASE; ADULTS; VARIABILITY; DYSFUNCTION;

D O I：

10.1016/j.etap.2024.104463

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (beta=-0.27 and -0.23, respectively, P<0.05). Additionally, negative associations were identified between mono-isobutyl phthalate and mono-butyl phthalate (MBP) and aspartate aminotransferase-to-alanine transaminase ratio (AST/ALT) (P<0.05). MBP and the sum of all phthalate metabolites (& sum;all.phth.m) were positively associated with bilirubin, with beta ranging from 0.14 to 0.47. Most phthalate metabolites were also positively related to gamma-glutamyl transferase (GGT) (all P<0.05). In Bayesian kernel machine regression models, phthalate mixture was positively associated with bilirubin and GGT, whereas inversely associated with AST/ALT and TP. Our results suggest that phthalate exposure may impair liver function among women undergoing ART.

引用

页数：9

共 73 条

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