Multicomponent Cross-Dehydrogenative Coupling of Imidazo[1,2-a]pyridine: Access to Abnormal Mannich and Mannich-Type Reaction

被引：3

作者：

Rahaman, Segufa ^{[1
]}

Sahay, Suhag Singh ^{[1
]}

Kumari, Annu ^{[1
]}

Dey, Swapan ^{[1
]}

机构：

[1] Indian Inst Technol, Indian Sch Mines, Dept Chem & Chem Biol, Dhanbad 826004, Jharkhand, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 15期

关键词：

C-H ACTIVATION; BIOLOGICAL EVALUATION; DERIVATIVES; CHEMISTRY; BONDS; IMIDAZOPYRIDINE; RECEPTORS; DESIGN;

D O I：

10.1021/acs.joc.4c01001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study showcases successfully switchable approaches to accomplish the C3-aryl methylation and C3-amino methylation of privileged nitrogen-containing pharmaceutical compounds "imidazopyridines" with distinct amines, which surmounts the long-standing requirement for a superfluous directing group. These two transformations manifest pronounced regio- and chemo-divergent behavior, successfully demonstrating unprecedented multicomponent "abnormal Mannich and Mannich-type" reactions. The remarkable environmentally benign protocol has been efficiently extended to concise the synthesis and late-stage derivatization.

引用

页码：10773 / 10784

页数：12

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