Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications

被引:6
|
作者
Varrias, Dimitrios [1 ]
Saralidze, Tinatin [1 ]
Borkowski, Pawel [1 ]
Pargaonkar, Sumant [1 ]
Spanos, Michail [2 ]
Bazoukis, George [3 ]
Kokkinidis, Damianos [4 ]
机构
[1] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Med, Bronx, NY 10461 USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
[3] European Univ Cyprus, Sch Med, CY-2404 Nicosia, Cyprus
[4] Yale Univ, Sect Cardiovasc Med, New Haven, CT 06520 USA
关键词
dementia; atrial fibrillation; Alzheimer's; stroke; bleeding; anticoagulation; ANTAGONIST ORAL ANTICOAGULANTS; SILENT CEREBRAL INFARCTIONS; CATHETER ABLATION; COGNITIVE DECLINE; INCIDENT DEMENTIA; LESS DEMENTIA; RISK-FACTOR; STROKE; ASSOCIATION; POPULATION;
D O I
10.3390/biom14040455
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Numerous longitudinal studies suggest a strong association between cardiovascular risk factors and cognitive impairment. Individuals with atrial fibrillation are at higher risk of dementia and cognitive dysfunction, as atrial fibrillation increases the risk of cerebral hypoperfusion, inflammation, and stroke. The lack of comprehensive understanding of the observed association and the complex relationship between these two diseases makes it very hard to provide robust guidelines on therapeutic indications. With this review, we attempt to shed some light on how atrial fibrillation is related to dementia, what we know regarding preventive interventions, and how we could move forward in managing those very frequently overlapping conditions.
引用
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页数:12
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