Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer

被引：13

作者：

Jiang, Ming ^{[1
]}

Su, Xiaoling ^{[1
]}

Zhong, Xuwei ^{[1
]}

Lan, Yahui ^{[1
]}

Yang, Feng ^{[2
]}

Qin, Yiming ^{[1
]}

Jiang, Caiyun ^{[1
]}

机构：

[1] Guangxi Sci & Technol Normal Univ, Sch Food & Biochem Engn, Laibin, Guangxi, Peoples R China

[2] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med,Minst Educ, Sch Chem & Pharmaceut Sci,Key Lab Chem & Mol Engn, State Key Lab Chem & Mol Engn Med Resources, Guilin, Guangxi, Peoples R China

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2024年 / 1318卷

关键词：

Lung cancer; Metal complex; Schiff-base; Anticancer; HALF-SANDWICH IRIDIUM(III); ANTICANCER ACTIVITY; COPPER-COMPLEXES; DNA-BINDING; CYTOTOXICITY; CHEMOTHERAPY; CISPLATIN; THIOSEMICARBAZONE; COMBINATION; CLEAVAGE;

D O I：

10.1016/j.molstruc.2024.139403

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Lung cancer, with its high global morbidity and mortality rates, poses a significant health challenge. Platinum drugs are one of the commonly used chemotherapy drugs. Unfortunately, their clinical effects are limited due to toxicity and drug resistance. Therefore, there has been a growing focus on the development of innovative metalbased anti-tumor drugs over the past decades. Among metal-based anticancer agents, Schiff-base metal complexes have gained considerable attention due to their significant antiproliferative potency and efficacy. These complexes leverage the combined advantages of Schiff base ligands and metal ions, demonstrating a diverse array of anti-tumor mechanisms. This review comprehensively summarizes the latest advancements in Schiffbase metal complexes, detailing their biological activities and the mechanisms underlying their action.

引用

页数：16

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