Epithelial-Myoepithelial Carcinoma of the Parotid Gland: A Report of a Rare Case and Review of Literature

被引:0
作者
Surolia, Prachi [1 ]
Kambala, Rajanikanth [1 ]
Bhola, Nitin [1 ]
机构
[1] Sharad Pawar Dent Coll & Hosp, Datta Meghe Inst Higher Educ & Res, Oral & Maxillofacial Surg, Wardha, India
关键词
recurrence local; neoplasm recurrence; head and neck neoplasms; salivary gland carcinoma; epithelial- myoepithelial carcinoma; SALIVARY-GLANDS; ADENOMA; TUMORS;
D O I
10.7759/cureus.59701
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epithelial-myoepithelial carcinoma (EMC) is a rare tumor, characterized by two different cell populations and both demonstrate a malignant nature microscopically. It constitutes less than 2% of all salivary gland malignancies. The World Health Organization (WHO) has classified this disease as a separate pathological category. The diagnosis of this tumor is arrived by biopsy. It shows slow growth and is small in size; it appears in ulcerative form of mucosa in some cases. Gland cells consist of two layers of outer myoepithelium cells and inner epithelial cells. Vimentin staining is positive. It shows calponin, muscle -specific actin, S100, smooth muscle actin, p63, and smooth muscle myosin heavy chain I. Examining different sets of data reveals that tumors exhibiting a solid growth pattern, nuclear atypia, DNA aneuploidy, and increased proliferative activity typically display a more aggressive nature, accompanied by a heightened likelihood of local recurrences and metastases. The clinical and radiological observations frequently resemble those of a benign tumor. Due to the uncommon nature of EMC, there is currently no established standard treatment protocol. It is considered a low-grade tumor where good resection holds better results. Individuals displaying histopathological indicators of aggressive disease should be evaluated for potential adjuvant radiotherapy. We present a case of a patient who had recurrence twice in a period of seven years despite surgical management, chemotherapy, and radiotherapy.
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页数:10
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