Telitacicept Treatment Refractory Lupus Nephritis: A Case Report

被引：3

作者：

Li, Sijia ^{[1
]}

Deng, Shuting ^{[2
]}

Wen, Sichun ^{[1
]}

Peng, Siqi ^{[1
]}

Jiang, Nan ^{[1
]}

Li, Bohou ^{[1
]}

Chen, Boxi ^{[1
]}

Yuan, Ye ^{[1
]}

Wu, Qiong ^{[1
]}

Tao, Yiming ^{[1
]}

Ma, Jianchao ^{[1
]}

Lin, Ting ^{[1
]}

Wen, Feng ^{[1
]}

Li, Zhuo ^{[1
]}

Dai, Hao ^{[1
]}

Huang, Renwei ^{[1
]}

Feng, Zhonglin ^{[1
]}

Li, Zhilian ^{[1
]}

Liu, Shuangxin ^{[1
]}

Xu, Lixia ^{[1
]}

机构：

[1] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Nephrol, Guangzhou, Peoples R China

[2] South China Univ Technol, Sch Med, Guangzhou, Peoples R China

来源：

CASE REPORTS IN NEPHROLOGY AND DIALYSIS | 2024年 / 14卷 / 01期

关键词：

Systemic lupus erythematosus; Refractory lupus nephritis; Telitacicept; Biologics; Treatment; MANAGEMENT;

D O I：

10.1159/000538033

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN. Case Presentation: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient. This patient with refractory lupus developed Pneumocystis jirovecii pneumonia while using multitargeted therapy, and the patient's urine protein was rapidly relieved after telitacicept combination with low-dose mycophenolate mofetil (MMF). Conclusion: This result suggests that telitacicept has a positive effect on refractory LN with no significant side effects. Further reports and a registry are necessary to confirm that telitacicept with low-dose MMF should be preferred in refractory LN.

引用

页码：42 / 47

页数：6

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