Plasma Asprosin Concentrations are Associated with Progression of Diabetic Kidney Disease

被引：1

作者：

Xu, Mingyue ^{[1
]}

Zhang, Chunlin ^{[1
]}

Zhang, Linlin ^{[1
]}

Qu, Hua ^{[1
]}

Wang, Yuren ^{[1
]}

机构：

[1] Army Med Univ, Affiliated Hosp 2, Chongqing Educ Commiss China, Dept Endocrinol,Translat Res Diabet Key Lab, Chongqing 400037, Peoples R China

来源：

DIABETES METABOLIC SYNDROME AND OBESITY | 2024年 / 17卷

基金：

中国国家自然科学基金;

关键词：

asprosin; diabetes; diabetic kidney disease; kidney injury; INFLAMMATION; MECHANISMS;

D O I：

10.2147/DMSO.S447465

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To explore the expression of asprosin in subjects with pre-DKD and DKD and to analyze its relationship with kidney injury, inflammation, and glucose and lipid metabolism. Methods: Based on urine albumin:creatinine ratio (UACr), participants were divided into DM, pre-DKD, and DKD groups. Relevant human physiological and biochemical parameters were detected in the three groups. Results: We found relatively higher levels of asprosin in both pre-DKD and DKD groups than the DM group. Moreover, data from the Nephroseq database support increased gene expression of asprosin in kidney tissue from DKD patients. Further correlation analysis revealed that the plasma asprosin level was positively correlated with age, waist circumference, waist:hip ratio, systolic blood pressure, creatinine, UACr, triglycerides, HDL-c, fasting insulin, HOMA-IR, and the inflammatory marker G3P and negatively associated with eGFR. Multiple logistical regression analysis showed that asprosin concentration was significantly associated with pre-DKD and DKD after adjusting for sex, age, BMI, WHR, and HOMA-IR, while this correlation was lost after controlling for G3P. Conclusion: Plasma asprosin is associated with kidney injury in diabetic conditions, and this association might be connected through inflammatory response. Further studies are needed to assess the role and mechanism of asprosin in DKD.

引用

页码：2235 / 2242

页数：8