Optical quality in vitro and in vivo of an extended depth-of-focus intraocular lens with isofocal design

PurposeThe aim of this study is to compare optical quality results obtained in laboratory analysis (in vitro) versus clinical data (in vivo).MethodsThe optical quality of ISOPure intraocular lens was assessed both in vitro and in vivo using the modulation transfer function (MTF) for 3.0 and 4.5 mm pupil diameters. In vitro measurements were obtained using deflectometer NIMO TRF1504, while in vivo measurements were taken with OPD-Scan III in a set of patients implanted with this lens. Ray tracing techniques were used to determine the MTF and area under MTF curve (MTFa) from the measured wavefront for the isolated lens and for the whole eye.ResultsThe MTF of the isolated lens obtained under both in vitro and in vivo conditions showed comparable results for both pupil sizes. However, differences were found when comparing the MTF of the whole eye with the lens implanted versus the MTF measured in vitro for 4.5 mm pupil size. Also, the MTFa defocus curve was compared with the defocus curve measured in vivo.ConclusionThe defocus curve from the in vivo study aligns closely with the MTFa of the in vitro model, with a useful defocus range of 0.40D. Thus, it is possible to anticipate the visual results of the implanted isofocal lens by using measurements on an optical bench and conducting optical simulations. What is known center dot Extended depth of focus (EDoF) lenses are prominent for expanding vision range in pseudophakic eyes, exceeding traditional limits.center dot The ISOPure lens is characterized as a bi-aspheric refractive design that produces an extended depth of focus design.What is new center dot The MTF of the isolated lens obtained under both in vitro and in vivo conditions showed comparable results.center dot The defocus curve from the in vivo study aligns closely with the MTFa of the in vitro model, with a useful defocus range of 0.40D.