Usefulness of aircraft and airport wastewater for monitoring multiple pathogens including SARS-CoV-2 variants

被引：8

作者：

Tay, Martin ^{[1
]}

Lee, Benjamin ^{[1
]}

Ismail, Muhammad Hafiz ^{[1
]}

Yam, Jerald ^{[1
]}

Maliki, Dzulkhairul ^{[1
]}

Gin, Karina Yew-Hoong ^{[2
,3
,4
]}

Chae, Sae-Rom ^{[5
,6
,7
]}

Ho, Zheng Jie Marc ^{[5
]}

Teoh, Yee Leong ^{[5
,6
]}

Ng, Lee Ching ^{[1
,8
]}

Wong, Judith Chui Ching ^{[1
]}

机构：

[1] Natl Environm Agcy, Environm Hlth Inst, Singapore 138667, Singapore

[2] Natl Univ Singapore, NUS Environm Res Inst, Singapore, Singapore

[3] Campus Res Excellence & Technol Enterprise CREATE, Energy & Environm Sustainabil Megac E2S2 Phase 2, Singapore, Singapore

[4] Natl Univ Singapore, Dept Civil & Environm Engn, Singapore, Singapore

[5] Minist Hlth, Communicable Dis Grp, Singapore, Singapore

[6] Natl Ctr Infect Dis, Singapore, Singapore

[7] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[8] Nanyang Technol Univ, Sch Biol Sci, Singapore, Singapore

来源：

JOURNAL OF TRAVEL MEDICINE | 2024年 / 31卷 / 05期

关键词：

Wastewater surveillance; epidemiology; global health; SARS-CoV-2; variants; infectious diseases; aircraft wastewater; SURVEILLANCE;

D O I：

10.1093/jtm/taae074

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background As global travel resumed in coronavirus disease 2019 (COVID-19) endemicity, the potential of aircraft wastewater monitoring to provide early warning of disease trends for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other infectious diseases, particularly at international air travel hubs, was recognized. We therefore assessed and compared the feasibility of testing wastewater from inbound aircraft and airport terminals for 18 pathogens including SARS-CoV-2 in Singapore, a popular travel hub in Asia.Methods Wastewater samples collected from inbound medium- and long-haul flights and airport terminals were tested for SARS-CoV-2. Next Generation Sequencing was carried out on positive samples to identify SARS-CoV-2 variants. Airport and aircraft samples were further tested for 17 other pathogens through quantitative reverse transcription polymerase chain reaction.Results The proportion of SARS-CoV-2-positive samples and the average virus load was higher for wastewater samples from aircraft as compared with airport terminals. Cross-correlation analyses indicated that viral load trends from airport wastewater led local COVID-19 case trends by 2-5 days. A total of 10 variants (44 sub-lineages) were successfully identified from aircraft wastewater and airport terminals, and four variants of interest and one variant under monitoring were detected in aircraft and airport wastewater 18-31 days prior to detection in local clinical cases. The detection of five respiratory and four enteric viruses in aircraft wastewater samples further underscores the potential to expand aircraft wastewater to monitoring pathogens beyond SARS-CoV-2.Conclusion Our findings demonstrate the feasibility of aircraft wastewater testing for monitoring infectious diseases threats, potentially detecting signals before clinical cases are reported. The triangulation of similar datapoints from aircraft wastewater of international travel nodes could therefore serve as a useful early warning system for global health threats.

引用

页数：8

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