Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

被引：28

作者：

Wang, Liyuan ^{[1
]}

Hao, Manjun ^{[1
]}

Wu, Na ^{[1
]}

Wu, Shuangzhe ^{[2
]}

Fisher, Marc ^{[3
]}

Xiong, Yunyun ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 119 West Sect South Fourth Ring Rd, Beijing 100070, Peoples R China

[2] Chinese Inst Brain Res, Beijing, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2024年 / 13卷 / 09期

关键词：

alteplase; ischemic stroke; tenecteplase; thrombolysis; TISSUE-PLASMINOGEN-ACTIVATOR; BLINDED END-POINT; OPEN-LABEL; INTRAVENOUS THROMBOLYSIS; NOR-TEST; ALTEPLASE; TRIAL; MANAGEMENT; METAANALYSIS; THERAPY;

D O I：

10.1161/JAHA.123.031692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated the favorable pharmacokinetics and pharmacodynamics of tenecteplase. Moreover, it is easier to administer. Clinical trials have demonstrated that tenecteplase is not inferior to alteplase and may even be superior in cases of acute ischemic stroke with large vessel occlusion. Current evidence supports the time and cost benefits of tenecteplase, suggesting that it could potentially replace alteplase as the main option for thrombolytic therapy, especially in patients with large vessel occlusion.

引用

页数：12

共 82 条

[61] Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection [J].

Ringleb, Peter ;

Bendszus, Martin ;

Bluhrnki, Erich ;

Donnan, Geoffrey ;

Eschenfelder, Christoph ;

Fatal, Marc ;

Kessler, Christof ;

Molina, Carlos ;

Leys, Didier ;

Muddegowda, Girish ;

Poh, Sven ;

Schellinger, Peter ;

Schwab, Stefan ;

Serena, Joaquin ;

Toni, Danilo ;

Wahlgren, Nils ;

Hacke, Werner .

INTERNATIONAL JOURNAL OF STROKE, 2019, 14 (05) :483-490

[62] Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial [J].

Roaldsen, Melinda B. ;

Eltoft, Agnethe ;

Wilsgaard, Tom ;

Christensen, Hanne ;

Engelter, Stefan T. ;

Indredavik, Bent ;

Jatuzis, Dalius ;

Karelis, Guntis ;

Korv, Janika ;

Lundstrom, Erik ;

Petersson, Jesper ;

Putaala, Jukka ;

Soyland, Mary-Helen ;

Tveiten, Arnstein ;

Bivard, Andrew ;

Johnsen, Stein Harald ;

Mazya, Michael, V ;

Werring, David J. ;

Wu, Teddy Y. ;

De Marchis, Gian Marco ;

Robinson, Thompson G. ;

Mathiesen, Ellisiv B. .

LANCET NEUROLOGY, 2023, 22 (02) :117-126

[63] The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial [J].

Sandercock, Peter ;

Wardlaw, Joanna M. ;

Lindley, Richard I. ;

Dennis, Martin ;

Cohen, Geoff ;

Murray, Gordon ;

Innes, Karen ;

Venables, Graham ;

Czlonkowska, Anna ;

Kobayashi, Adam ;

Ricci, Stefano ;

Murray, Veronica ;

Berge, Eivind ;

Slot, Karsten Bruins ;

Hankey, Graeme J. ;

Correia, Manuel ;

Peeters, Andre ;

Matz, Karl ;

Lyrer, Phillippe ;

Gubitz, Gord ;

Phillips, Stephen J. ;

Arauz, Antonio ;

Baigent, Colin ;

Chadwick, David ;

Tyrrell, Pippa ;

Lowe, Gordon ;

Farrall, Andrew ;

von Kummer, Rudiger ;

Cala, Lesley ;

von Heijne, Anders ;

Morris, Zoe ;

Adami, Alessandro ;

Potter, Gillian ;

Brady, Nick ;

Collins, Rory ;

Bath, Philip ;

van Gijn, Jan ;

Gray, Richard ;

Hart, Robert ;

Yusuf, Salim ;

Muir, Keith ;

Brainin, Michael ;

Engelter, Stefan ;

Terent, Andreas ;

Norrving, Bo ;

Wester, Per ;

Clark, Alison ;

Perry, David ;

Soosay, Vera ;

Buchanan, David .

LANCET, 2012, 379 (9834) :2352-2363

[64] Tenecteplase for acute ischaemic stroke [J].

Sandset, Else Charlotte ;

Tsivgoulis, Georgios .

LANCET, 2022, 400 (10347) :138-139

[65] Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial [J].

Saver, Jeffrey L. ;

Jahan, Reza ;

Levy, Elad I. ;

Jovin, Tudor G. ;

Baxter, Blaise ;

Nogueira, Raul G. ;

Clark, Wayne ;

Budzik, Ronald ;

Zaidat, Osama O. .

LANCET, 2012, 380 (9849) :1241-1249

[66] Identification of the mechanism responsible for the increased fibrin specificity of TNK-tissue plasminogen activator relative to tissue plasminogen activator [J].

Stewart, RJ ;

Fredenburgh, JC ;

Leslie, BA ;

Keyt, BA ;

Rischke, JA ;

Weitz, JI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10112-10120

[67] Tenecteplase or Alteplase Better in Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion: A Single Center Observational Study [J].

Teivane, Agnete ;

Jurjans, Kristaps ;

Vetra, Janis ;

Grigorjeva, Jekaterina ;

Kupcs, Karlis ;

Masiliunas, Rytis ;

Miglane, Evija .

MEDICINA-LITHUANIA, 2022, 58 (09)

[68] MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset [J].

Thomalla, G. ;

Simonsen, C. Z. ;

Boutitie, F. ;

Andersen, G. ;

Berthezene, Y. ;

Cheng, B. ;

Cheripelli, B. ;

Cho, T. -H. ;

Fazekas, F. ;

Fiehler, J. ;

Ford, I. ;

Galinovic, I. ;

Gellissen, S. ;

Golsari, A. ;

Gregori, J. ;

Guenther, M. ;

Guibernau, J. ;

Haeusler, K. G. ;

Hennerici, M. ;

Kemmling, A. ;

Marstrand, J. ;

Modrau, B. ;

Neeb, L. ;

de la Ossa, N. Perez ;

Puig, J. ;

Ringleb, P. ;

Roy, P. ;

Scheel, E. ;

Schonewille, W. ;

Serena, J. ;

Sunaert, S. ;

Villringer, K. ;

Wouters, A. ;

Thijs, V. ;

Ebinger, M. ;

Endres, M. ;

Fiebach, J. B. ;

Lemmens, R. ;

Muir, K. W. ;

Nighoghossian, N. ;

Pedraza, S. ;

Gerloff, C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (07) :611-622

[69] A LONG-HALF-LIFE AND FIBRIN-SPECIFIC FORM OF TISSUE-PLASMINOGEN ACTIVATOR IN RABBIT MODELS OF EMBOLIC STROKE AND PERIPHERAL BLEEDING [J].

THOMAS, GR ;

THIBODEAUX, H ;

ERRETT, CJ ;

BADILLO, JM ;

KEYT, BA ;

REFINO, CJ ;

ZIVIN, JA ;

BENNETT, WF .

STROKE, 1994, 25 (10) :2072-2078

[70] Tenecteplase versus alteplase after acute ischemic stroke at high age [J].

Thommessen, Bente ;

Naess, Halvor ;

Logallo, Nicola ;

Kvistad, Christopher E. ;

Waje-Andreassen, Ulrike ;

Ihle-Hansen, Hege ;

Ihle-Hansen, Hakon ;

Thomassen, Lars ;

Ronning, Ole Morten .

INTERNATIONAL JOURNAL OF STROKE, 2021, 16 (03) :295-299

← 1 2 3 4 5 6 7 8 9 →