Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

被引：28

作者：

Wang, Liyuan ^{[1
]}

Hao, Manjun ^{[1
]}

Wu, Na ^{[1
]}

Wu, Shuangzhe ^{[2
]}

Fisher, Marc ^{[3
]}

Xiong, Yunyun ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 119 West Sect South Fourth Ring Rd, Beijing 100070, Peoples R China

[2] Chinese Inst Brain Res, Beijing, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2024年 / 13卷 / 09期

关键词：

alteplase; ischemic stroke; tenecteplase; thrombolysis; TISSUE-PLASMINOGEN-ACTIVATOR; BLINDED END-POINT; OPEN-LABEL; INTRAVENOUS THROMBOLYSIS; NOR-TEST; ALTEPLASE; TRIAL; MANAGEMENT; METAANALYSIS; THERAPY;

D O I：

10.1161/JAHA.123.031692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated the favorable pharmacokinetics and pharmacodynamics of tenecteplase. Moreover, it is easier to administer. Clinical trials have demonstrated that tenecteplase is not inferior to alteplase and may even be superior in cases of acute ischemic stroke with large vessel occlusion. Current evidence supports the time and cost benefits of tenecteplase, suggesting that it could potentially replace alteplase as the main option for thrombolytic therapy, especially in patients with large vessel occlusion.

引用

页数：12

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