Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

被引：28

作者：

Wang, Liyuan ^{[1
]}

Hao, Manjun ^{[1
]}

Wu, Na ^{[1
]}

Wu, Shuangzhe ^{[2
]}

Fisher, Marc ^{[3
]}

Xiong, Yunyun ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, 119 West Sect South Fourth Ring Rd, Beijing 100070, Peoples R China

[2] Chinese Inst Brain Res, Beijing, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2024年 / 13卷 / 09期

关键词：

alteplase; ischemic stroke; tenecteplase; thrombolysis; TISSUE-PLASMINOGEN-ACTIVATOR; BLINDED END-POINT; OPEN-LABEL; INTRAVENOUS THROMBOLYSIS; NOR-TEST; ALTEPLASE; TRIAL; MANAGEMENT; METAANALYSIS; THERAPY;

D O I：

10.1161/JAHA.123.031692

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase. Animal studies have demonstrated the favorable pharmacokinetics and pharmacodynamics of tenecteplase. Moreover, it is easier to administer. Clinical trials have demonstrated that tenecteplase is not inferior to alteplase and may even be superior in cases of acute ischemic stroke with large vessel occlusion. Current evidence supports the time and cost benefits of tenecteplase, suggesting that it could potentially replace alteplase as the main option for thrombolytic therapy, especially in patients with large vessel occlusion.

引用

页数：12

共 82 条

[1] Clinical outcomes and safety profile of Tenecteplase in wake-up stroke [J].

Ahmed, Hassan Khan ;

Logallo, Nicola ;

Thomassen, Lars ;

Novotny, Vojtech ;

Mathisen, Sara M. ;

Kurz, Martin W. .

ACTA NEUROLOGICA SCANDINAVICA, 2020, 142 (05) :475-479

[2] European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke [J].

Alamowitch, Sonia ;

Turc, Guillaume ;

Palaiodimou, Lina ;

Bivard, Andrew ;

Cameron, Alan ;

De Marchis, Gian Marco ;

Fromm, Annette ;

Korv, Janika ;

Roaldsen, Melinda B. ;

Katsanos, Aristeidis H. ;

Tsivgoulis, Georgios .

EUROPEAN STROKE JOURNAL, 2023, 8 (01) :8-54

[3] Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection [J].

Albers, Gregory W. ;

Jumaa, Mouhammad ;

Purdon, Barbara ;

Zaidi, Syed F. ;

Streib, Christopher ;

Shuaib, Ashfaq ;

Sangha, Navdeep ;

Kim, Minjee ;

Froehler, Michael T. ;

Schwartz, Neil E. ;

Clark, Wayne M. ;

Kircher, Charles E. ;

Yang, Ming ;

Massaro, Lori ;

Lu, Xiao-Yu ;

Rippon, Gregory A. ;

Broderick, Joseph P. ;

Butcher, Ken ;

Lansberg, Maarten G. ;

Liebeskind, David S. ;

Nouh, Amre ;

Schwamm, Lee H. ;

Campbell, Bruce C. V. .

NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (08) :701-711

[4]

American Academy of Emergency Medicine Work Group on Thrombolytic Therapy in Stroke, Position Statement of the American Academy of Emergency Medicine on the Use of Intravenous Thrombolytic Therapy in the Treatment of Stroke

[5] Plasminogen activators: A comparison [J].

Baruah, DB ;

Dash, RN ;

Chaudhari, MR ;

Kadam, SS .

VASCULAR PHARMACOLOGY, 2006, 44 (01) :1-9

[6] Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital [J].

Belkouch, Ahmed ;

Jidane, Said ;

Chouaib, Naoufal ;

Elbouti, Anass ;

Nebhani, Tahir ;

Sirbou, Rachid ;

Bakkali, Hicham ;

Belyamani, Lahcen .

PAN AFRICAN MEDICAL JOURNAL, 2015, 21

[7] NEW VARIANT OF HUMAN TISSUE-PLASMINOGEN ACTIVATOR (TPA) WITH ENHANCED EFFICACY AND LOWER INCIDENCE OF BLEEDING COMPARED WITH RECOMBINANT HUMAN TPA [J].

BENEDICT, CR ;

REFINO, CJ ;

KEYT, BA ;

PAKALA, R ;

PAONI, NF ;

THOMAS, GR ;

BENNETT, WF .

CIRCULATION, 1995, 92 (10) :3032-3040

[8] European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke [J].

Berge, Eivind ;

Whiteley, William ;

Audebert, Heinrich ;

Marchis, Gian Marco De ;

Fonseca, Ana Catarina ;

Padiglioni, Chiara ;

Ossa, Natalia Perez de la ;

Strbian, Daniel ;

Tsivgoulis, Georgios ;

Turc, Guillaume .

EUROPEAN STROKE JOURNAL, 2021, 6 (01) :I-LXII

[9] Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial [J].

Bivard, Andrew ;

Zhao, Henry ;

Churilov, Leonid ;

Campbell, Bruce C., V ;

Coote, Skye ;

Yassi, Nawaf ;

Yan, Bernard ;

Valente, Michael ;

Sharobeam, Angelos ;

Balabanski, Anna H. ;

Dos Santos, Angela ;

Ng, Jo Lyn ;

Yogendrakumar, Vignan ;

Ng, Felix ;

Langenberg, Francesca ;

Easton, Damien ;

Warwick, Alex ;

Mackey, Elizabeth ;

MacDonald, Amy ;

Sharma, Gagan ;

Stephenson, Michael ;

Smith, Karen ;

Anderson, David ;

Choi, Philip ;

Thijs, Vincent ;

Ma, Henry ;

Cloud, Geoffrey C. ;

Wijeratne, Tissa ;

Olenko, Liudmyla ;

Italiano, Dominic ;

Davis, Stephen M. ;

Donnan, Geoffrey A. ;

Parsons, Mark W. .

LANCET NEUROLOGY, 2022, 21 (06) :520-527

[10] Tenecteplase in ischemic stroke offers improved recanalization Analysis of 2 trials [J].

Bivard, Andrew ;

Huang, Xuya ;

Levi, Christopher R. ;

Spratt, Neil ;

Campbell, Bruce C. V. ;

Cheripelli, Bharath Kumar ;

Kalladka, Dheeraj ;

Moreton, Fiona Catherine ;

Ford, Ian ;

Bladin, Christopher F. ;

Davis, Stephen M. ;

Donnan, Geoffrey A. ;

Muir, Keith W. ;

Parsons, Mark W. .

NEUROLOGY, 2017, 89 (01) :62-67

← 1 2 3 4 5 6 7 8 9 →