Biomarkers for Diagnosing and Treating Fetal Growth Restriction

被引：2

作者：

Wu, Mengyao ^{[1
]}

He, Junyu ^{[2
]}

Chen, Yetao ^{[1
]}

Wan, Fangzhu ^{[1
]}

Tang, Hongbo ^{[3
]}

Yin, Chenghong ^{[3
]}

He, Haibo ^{[1
,4
]}

Yu, Huifan ^{[4
]}

Yuan, Chengfu ^{[2
]}

机构：

[1] China Three Gorges Univ, Coll Biol Pharm, Yichang Key Lab Dev & Utilizat Hlth Prod Drug & F, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] China Three Gorges Univ, Basic Med Coll, Yichang 443002, Peoples R China

[3] Capital Med Univ, Beijing Maternal & Child Hlth Care Hosp, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China

[4] Hubei Univ Med, Coll Biol Pharm, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 28期

关键词：

Biomarkers; fetal growth restriction; predicted; pharmacological mechanism; placenta; pregnancy complication; INFLAMMASOME ACTIVATION; BIRTH-WEIGHT; PREGNANCY; PREECLAMPSIA; CELLS; WOMEN; PPAR; DLK1;

D O I：

10.2174/0109298673258444231019104656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fetal growth restriction (FGR), a common obstetric complication, significantly increases the risks of fetal intrauterine death and neonatal death, and fetuses with growth restriction are prone to cognitive retardation and various diseases in adulthood. The early determination of FGR risk is contentious in clinical research, and few indicators are available for the early prediction and diagnosis of FGR. This review focuses on the prediction and diagnosis of FGR, as well as the significance of biomarkers for FGR, such as those related to gene regulation, apoptosis, mitochondrial function, and inflammation. Although many of these biomarkers are still in the early stages of research, they are good predictors of the threats to fetal health and safety, and they provide new insights for the treatment of FGR.

引用

页码：4461 / 4478

页数：18

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