Biomarkers for Diagnosing and Treating Fetal Growth Restriction

被引：2

作者：

Wu, Mengyao ^{[1
]}

He, Junyu ^{[2
]}

Chen, Yetao ^{[1
]}

Wan, Fangzhu ^{[1
]}

Tang, Hongbo ^{[3
]}

Yin, Chenghong ^{[3
]}

He, Haibo ^{[1
,4
]}

Yu, Huifan ^{[4
]}

Yuan, Chengfu ^{[2
]}

机构：

[1] China Three Gorges Univ, Coll Biol Pharm, Yichang Key Lab Dev & Utilizat Hlth Prod Drug & F, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] China Three Gorges Univ, Basic Med Coll, Yichang 443002, Peoples R China

[3] Capital Med Univ, Beijing Maternal & Child Hlth Care Hosp, Beijing Obstet & Gynecol Hosp, Beijing 100026, Peoples R China

[4] Hubei Univ Med, Coll Biol Pharm, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2024年 / 31卷 / 28期

关键词：

Biomarkers; fetal growth restriction; predicted; pharmacological mechanism; placenta; pregnancy complication; INFLAMMASOME ACTIVATION; BIRTH-WEIGHT; PREGNANCY; PREECLAMPSIA; CELLS; WOMEN; PPAR; DLK1;

D O I：

10.2174/0109298673258444231019104656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fetal growth restriction (FGR), a common obstetric complication, significantly increases the risks of fetal intrauterine death and neonatal death, and fetuses with growth restriction are prone to cognitive retardation and various diseases in adulthood. The early determination of FGR risk is contentious in clinical research, and few indicators are available for the early prediction and diagnosis of FGR. This review focuses on the prediction and diagnosis of FGR, as well as the significance of biomarkers for FGR, such as those related to gene regulation, apoptosis, mitochondrial function, and inflammation. Although many of these biomarkers are still in the early stages of research, they are good predictors of the threats to fetal health and safety, and they provide new insights for the treatment of FGR.

引用

页码：4461 / 4478

页数：18

共 115 条

[1] Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice [J].

Addis, Dylan R. ;

Lambert, James A. ;

Ren, Changchun ;

Doran, Stephen ;

Aggarwal, Saurabh ;

Jilling, Tamas ;

Matalon, Sadis .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (03)

[2] The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction [J].

Alfian, Irvan ;

Chakraborty, Amlan ;

Yong, Hannah E. J. ;

Saini, Sheetal ;

Lau, Ricky W. K. ;

Kalionis, Bill ;

Dimitriadis, Evdokia ;

Alfaidy, Nadia ;

Ricardo, Sharon D. ;

Samuel, Chrishan S. ;

Murthi, Padma .

CELLS, 2022, 11 (09)

[3] Tracking placental development in health and disease [J].

Aplin, John D. ;

Myers, Jenny E. ;

Timms, Kate ;

Westwood, Melissa .

NATURE REVIEWS ENDOCRINOLOGY, 2020, 16 (09) :479-494

[4] Placental apoptosis in recurrent miscarriage [J].

Atia, Tarek A. .

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2017, 33 (09) :449-452

[5] Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats [J].

Bao, Junjie ;

Zou, Yong ;

Liu, Yuanyuan ;

Yuan, Li ;

Garfield, Robert E. ;

Liu, Huishu .

BIOSCIENCE REPORTS, 2019, 39

[6] HLA-CKIR interactions and placental defects: Implications in ART pregnancy issues [J].

Barry, F. ;

Benart, L. ;

Robert, L. ;

Gala, A. ;

Ferrieres-Hoa, A. ;

Loup, V ;

Anahory, T. ;

Brouillet, S. ;

Hamamah, S. .

GYNECOLOGIE OBSTETRIQUE FERTILITE & SENOLOGIE, 2022, 50 (09) :600-609

[7] National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis [J].

Blencowe, Hannah ;

Krasevec, Julia ;

de Onis, Mercedes ;

Black, Robert E. ;

An, Xiaoyi ;

Stevens, Gretchen A. ;

Borghi, Elaine ;

Hayashi, Chika ;

Estevez, Diana ;

Cegolon, Luca ;

Shiekh, Suhail ;

Hardy, Victoria Ponce ;

Lawn, Joy E. ;

Cousens, Simon .

LANCET GLOBAL HEALTH, 2019, 7 (07) :E849-E860

[8] Vascular endothelial growth factor and its receptors regulation in gestational diabetes mellitus and eclampsia [J].

Bolatai, Alayi ;

He, Yujing ;

Wu, Na .

JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)

[9] Angiogenic factors for planning fetal surveillance in fetal growth restriction and small-for-gestational-age fetuses: A prospective observational study [J].

Bonacina, Erika ;

Mendoza, Manel ;

Farras, Alba ;

Garcia-Manau, Pablo ;

Serrano, Berta ;

Hurtado, Ivan ;

Ferrer-Oliveras, Raquel ;

Illan, Lidia ;

Armengol-Alsina, Mireia ;

Carreras, Elena .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2022, 129 (11) :1870-1877

[10] Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics [J].

Borowski, Sophia ;

Tirado-Gonzalez, Irene ;

Freitag, Nancy ;

Garcia, Mariana G. ;

Barrientos, Gabriela ;

Blois, Sandra M. .

FRONTIERS IN IMMUNOLOGY, 2020, 11

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