Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity

被引：3

作者：

Boen, Hanne M. ^{[1
,2
,5
]}

Cherubin, Martina ^{[3
]}

Franssen, Constantijn ^{[1
,2
]}

Gevaert, Andreas B. ^{[1
,2
]}

Witvrouwen, Isabel ^{[1
,2
]}

Bosman, Matthias ^{[4
]}

Guns, Pieter-Jan ^{[4
]}

Heidbuchel, Hein ^{[1
,2
]}

Loeys, Bart ^{[3
]}

Alaerts, Maaike ^{[3
]}

Van Craenenbroeck, Emeline M. ^{[2
]}

机构：

[1] Univ Antwerp, Res Grp Cardiovasc Dis, GENCOR, Antwerp, Belgium

[2] Antwerp Univ Hosp, Dept Cardiol, Antwerp, Belgium

[3] Univ Antwerp, Centrum Med Genet, GENCOR, Antwerp, Belgium

[4] Univ Antwerp, Lab Physiopharmacol, GENCOR, Antwerp, Belgium

[5] Cardiol UZA, Drie Eikenstr 655, B-2650 Edegem, Belgium

来源：

JACC: CARDIOONCOLOGY | 2024年 / 6卷 / 02期

基金：

欧洲研究理事会;

关键词：

cardiomyopathy; cardiotoxicity; chemotherapy; circulating biomarkers; epigenetics; heart failure; DOXORUBICIN-INDUCED CARDIOTOXICITY; BREAST-CANCER PATIENTS; INDUCED HEART-FAILURE; MYOCARDIAL-INFARCTION; CARDIOMYOCYTE APOPTOSIS; MULTIPLE BIOMARKERS; PEDIATRIC-PATIENTS; ENDOTHELIAL-CELLS; CARDIAC REPAIR; MIRNA;

D O I：

10.1016/j.jaccao.2023.12.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Close monitoring for cardiotoxicity during anthracycline chemotherapy is crucial for early diagnosis and therapy guidance. Currently, monitoring relies on cardiac imaging and serial measurement of cardiac biomarkers like cardiac troponin and natriuretic peptides. However, these conventional biomarkers are nonspecific indicators of cardiac damage. Exploring new, more specific biomarkers with a clear link to the underlying pathomechanism of cardiotoxicity holds promise for increased specificity and sensitivity in detecting early anthracycline-induced cardiotoxicity. miRNAs (microRNAs), small singlestranded, noncoding RNA sequences involved in epigenetic regulation, influence various physiological and pathological processes by targeting expression and translation. Emerging as new biomarker candidates, circulating miRNAs exhibit resistance to degradation and offer a direct pathomechanistic link. This review comprehensively outlines their potential as early biomarkers for cardiotoxicity and their pathomechanistic link. (J Am Coll Cardiol CardioOnc 2024;6:183-199) (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：183 / 199

页数：17

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