Characterization of Two Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Forms Among Men Who Have Sex with Men and Mother-to-Child Transmission Cases in Baoding City, China

被引：0

作者：

Jia, Jianru ^{[1
]}

Yang, Huijuan ^{[1
]}

Zhang, Zhen ^{[1
]}

Shi, Haoxi ^{[2
]}

Chen, Sisi ^{[2
]}

Shi, Penghui ^{[2
]}

Fan, Weiguang ^{[2
]}

机构：

[1] Peoples Hosp Baoding, Infect Div, Baoding, Hebei, Peoples R China

[2] Peoples Hosp Baoding, Clin Lab, Baoding 071000, Hebei, Peoples R China

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2025年 / 41卷 / 01期

关键词：

HIV-1; CRF01_AE/CRF07_BC; men who have sex with men; mother-to-child transmission;

D O I：

10.1089/aid.2024.0059

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CRF01_AE and CRF07_BC are predominant circulating HIV-1 subtypes in China. In this study, we report two novel HIV-1 CRF01_AE/CRF07_BC recombinant forms isolated from one man who has sex with men (MSM) (BDD027) and one mother-to-child transmission (MTCT) case (BDL123) in Baoding City, Hebei Province, China. The recombination breakpoint analysis showed that the recombination pattern of the near-full-length genome of BDD027 consisted of two CRF07_BC fragments inserted into a CRF01_AE backbone, while the recombination pattern of the near-full-length genome of BDL123 consisted of one CRF01_AE fragment inserted into a CRF07_BC backbone. This study demonstrates the importance of strengthening the monitoring of HIV-1 molecular epidemiological characteristics and emphasizes the urgent need to reduce the HIV-1 epidemic among MSM and MTCT populations in China.

引用

页码：55 / 59

页数：5

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