Integrin receptor-targeted, doxorubicin-loaded cerium oxide nanoparticles delivery to combat glioblastoma

被引：1
|
作者：
Koula, Gayathri [1 ,3 ]
Yakati, Venu [1 ,3 ]
Rachamalla, Hari Krishnareddy [1 ,3 ]
Bhamidipati, Keerti [2 ,3 ]
Kathirvel, Muralidharan [2 ]
Banerjee, Rajkumar [1 ]
Puvvada, Nagaprasad [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Dept Oils Lipids Sci & Technol, Hyderabad 500007, India
[2] Indian Inst Chem Technol, CSIR, Appl Biol Div, Hyderabad 500007, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Utar Pradesh UP, India
来源：
NANOMEDICINE | 2024年 / 19卷 / 15期
关键词：
blood-brain barrier; cerium oxide nanoparticles; cyclic RGDfK peptide; glioblastoma multiforme; tumor-associated macrophages; tumor microenvironment; CELLS; CANCER; SYSTEM;
D O I：
10.1080/17435889.2024.2350357
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To assess the chemo-immunomodulatory effects of doxorubicin-loaded cerium oxide nanoparticles coated with oleyl amine-linked cyclic RGDfK peptide (CeNP+Dox+RGD) to target both gliomas and its tumor microenvironment (TME) via integrin receptors. Materials & methods: CeNP+Dox+RGD nanoparticles are synthesized by the sequential addition of cerium III chloride heptahydrate, beta-cyclodextrin, oleic acid, and F127 micelle (CeNP). Doxorubicin was then loaded into CeNPs and coated with oleyl amine-linked cyclic RGDfK peptide to form stable CeNP+Dox+RGD nanoparticles. Results: CeNP+Dox+RGD nanoparticles crossed blood-brain barrier (BBB) effectively and demonstrated threefold enhanced survivability in glioma-bearing mice. The IHC profiling of glial tumor cross-sections showed increased CD80 expression (M1 TAMs) and decreased arginase-1 expression (M2 TAMs). Conclusion: CeNP+Dox+RGD can be an immunotherapeutic treatment option to combat glioblastoma.
引用
收藏
页码：1389 / 1406
页数：18
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