The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

被引:8
|
作者
Rakotoarivelo, Volatiana [1 ,2 ]
Mayer, Thomas Z. [1 ,2 ,3 ,4 ]
Simard, Melissa [1 ,2 ]
Flamand, Nicolas [1 ,2 ]
Di Marzo, Vincenzo [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Laval, Ctr Rech Inst, Dept Med, Univ Cardiol & Pneumol Quebec, Quebec City, PQ G1V 4G5, Canada
[2] Univ Laval, Canada Excellence Res Chair Microbiome Endocannabi, Quebec City, PQ G1V 0V6, Canada
[3] Univ Laval, Ecole Nutr, Inst Nutr & Aliments Fonct, Quebec City, PQ G1V 0V6, Canada
[4] Univ Laval, Ecole Nutr, Ctr NUTRISS, Quebec City, PQ G1V 0V6, Canada
[5] Joint Int Unit CNR Italy & Univ Laval, Chem & Biomol Res Microbiome & Its Impact Metab H, Quebec City, PQ G1V 0V6, Canada
来源
MOLECULES | 2024年 / 29卷 / 14期
基金
加拿大健康研究院;
关键词
inflammatory diseases; inflammation; cannabinoid; endocannabinoid; cannabinoid receptor; ACID AMIDE HYDROLASE; ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL; MONOGLYCERIDE LIPASE DEFICIENCY; INNATE LYMPHOID-CELLS; FATTY LIVER-DISEASE; TYPE-2; RECEPTOR; MURINE MODEL; ENDOCANNABINOID SYSTEM; EXPERIMENTAL COLITIS; NOLADIN ETHER;
D O I
10.3390/molecules29143381
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout. Since the characterization of cannabinoid receptors, CB1 and CB2, the potential of cannabinoid pharmacotherapy in inflammatory conditions has received great interest. Several studies have identified the importance of these receptors in immune cell migration and in the production of inflammatory mediators. As the presence of the CB2 receptor was documented to be more predominant in immune cells, several pharmacological agonists and antagonists have been designed to treat inflammation. To better define the potential of the CB2 receptor, three online databases, PubMed, Google Scholar and clinicaltrial.gov, were searched without language restriction. The full texts of articles presenting data on the endocannabinoid system, the CB2 receptor and its role in modulating inflammation in vitro, in animal models and in the context of clinical trials were reviewed. Finally, we discuss the clinical potential of the latest cannabinoid-based therapies in inflammatory diseases.
引用
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页数:36
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