The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

被引:8
|
作者
Rakotoarivelo, Volatiana [1 ,2 ]
Mayer, Thomas Z. [1 ,2 ,3 ,4 ]
Simard, Melissa [1 ,2 ]
Flamand, Nicolas [1 ,2 ]
Di Marzo, Vincenzo [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Laval, Ctr Rech Inst, Dept Med, Univ Cardiol & Pneumol Quebec, Quebec City, PQ G1V 4G5, Canada
[2] Univ Laval, Canada Excellence Res Chair Microbiome Endocannabi, Quebec City, PQ G1V 0V6, Canada
[3] Univ Laval, Ecole Nutr, Inst Nutr & Aliments Fonct, Quebec City, PQ G1V 0V6, Canada
[4] Univ Laval, Ecole Nutr, Ctr NUTRISS, Quebec City, PQ G1V 0V6, Canada
[5] Joint Int Unit CNR Italy & Univ Laval, Chem & Biomol Res Microbiome & Its Impact Metab H, Quebec City, PQ G1V 0V6, Canada
来源
MOLECULES | 2024年 / 29卷 / 14期
基金
加拿大健康研究院;
关键词
inflammatory diseases; inflammation; cannabinoid; endocannabinoid; cannabinoid receptor; ACID AMIDE HYDROLASE; ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL; MONOGLYCERIDE LIPASE DEFICIENCY; INNATE LYMPHOID-CELLS; FATTY LIVER-DISEASE; TYPE-2; RECEPTOR; MURINE MODEL; ENDOCANNABINOID SYSTEM; EXPERIMENTAL COLITIS; NOLADIN ETHER;
D O I
10.3390/molecules29143381
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout. Since the characterization of cannabinoid receptors, CB1 and CB2, the potential of cannabinoid pharmacotherapy in inflammatory conditions has received great interest. Several studies have identified the importance of these receptors in immune cell migration and in the production of inflammatory mediators. As the presence of the CB2 receptor was documented to be more predominant in immune cells, several pharmacological agonists and antagonists have been designed to treat inflammation. To better define the potential of the CB2 receptor, three online databases, PubMed, Google Scholar and clinicaltrial.gov, were searched without language restriction. The full texts of articles presenting data on the endocannabinoid system, the CB2 receptor and its role in modulating inflammation in vitro, in animal models and in the context of clinical trials were reviewed. Finally, we discuss the clinical potential of the latest cannabinoid-based therapies in inflammatory diseases.
引用
收藏
页数:36
相关论文
共 50 条
  • [31] Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders
    Ishiguro, Hiroki
    Horiuchi, Yasue
    Tabata, Koichi
    Liu, Qing-Rong
    Arinami, Tadao
    Onaivi, Emmanuel S.
    MOLECULES, 2018, 23 (08)
  • [32] Cannabinoid CB2 Receptor as a New Phototherapy Target for the Inhibition of Tumor Growth
    Jia, Ningyang
    Zhang, Shaojuan
    Shao, Pin
    Bagia, Christina
    Janjic, Jelena M.
    Ding, Ying
    Bai, Mingfeng
    MOLECULAR PHARMACEUTICS, 2014, 11 (06) : 1919 - 1929
  • [33] Sulfonamide derivatives as new potent and selective CB2 cannabinoid receptor agonists
    Ohta, Hiroshi
    Ishizaka, Tomoko
    Yoshinaga, Mitsukane
    Morita, Aki
    Tomishima, Yasumitsu
    Toda, Yoshihisa
    Saitoa, Shuj
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (18) : 5133 - 5135
  • [34] Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats
    Zhang, Hai-Ying
    Gao, Ming
    Shen, Hui
    Bi, Guo-Hua
    Yang, Hong-Ju
    Liu, Qing-Rong
    Wu, Jie
    Gardner, Eliot L.
    Bonci, Antonello
    Xi, Zheng-Xiong
    ADDICTION BIOLOGY, 2017, 22 (03) : 752 - 765
  • [35] Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei
    Baek, Jean-Ha
    Zheng, Yiwen
    Darlington, Cynthia L.
    Smith, Paul F.
    ACTA OTO-LARYNGOLOGICA, 2008, 128 (09) : 961 - 967
  • [36] Antibody testing for brain immunohistochemistry: Brain immunolabeling for the cannabinoid CB2 receptor
    Baek, Jean-Ha
    Darlington, Cynthia L.
    Smith, Paul F.
    Ashton, John C.
    JOURNAL OF NEUROSCIENCE METHODS, 2013, 216 (02) : 87 - 95
  • [37] CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease
    Aso, Ester
    Ferrer, Isidro
    FRONTIERS IN NEUROSCIENCE, 2016, 10
  • [38] Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor
    Carrasquer, Alex
    Nebane, Nstang M.
    Williams, Walter M.
    Song, Zhao-Hui
    PHARMACOGENETICS AND GENOMICS, 2010, 20 (03) : 157 - 166
  • [39] CB1 AND CB2 CANNABINOID RECEPTOR EXPRESSION DURING DEVELOPMENT AND IN EPILEPTOGENIC DEVELOPMENTAL PATHOLOGIES
    Zurolo, E.
    Iyer, A. M.
    Spliet, W. G. M.
    Van Rijen, P. C.
    Troost, D.
    Gorter, J. A.
    Aronica, E.
    NEUROSCIENCE, 2010, 170 (01) : 28 - 41
  • [40] CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes
    Heinemann, Jan C.
    Duerr, Georg D.
    Keppel, Katharina
    Breitbach, Martin
    Fleischmann, Bernd K.
    Zimmer, Andreas
    Wehner, Sven
    Welz, Armin
    Dewald, Oliver
    LIFE SCIENCES, 2015, 138 : 18 - 28