Delay in the fine-tuning of locomotion in infants with meconium positive to biomarkers of alcohol exposure: a pilot study

被引：0

作者：

Coriale, Giovanna ^{[1
]}

Ceccanti, Mauro ^{[2
]}

Fiore, Marco ^{[3
]}

Tarani, Francesca ^{[4
]}

Micangeli, Ginevra ^{[4
]}

Menghi, Michela ^{[4
]}

Minutillo, Adele ^{[5
]}

Berretta, Paolo ^{[5
]}

Ferraguti, Giampiero ^{[6
]}

Iannitelli, Angela ^{[7
]}

Parlapiano, Giovanni ^{[4
]}

Paparella, Roberto ^{[4
]}

Messina, Marisa patrizia ^{[4
]}

Vitali, Mario ^{[8
]}

Fiorentino, Daniela ^{[9
]}

Pichini, Simona ^{[5
]}

Tarani, Luigi ^{[4
]}

机构：

[1] ASL Roma 1, CRARL Lazio, Rome, Italy

[2] Soc Italiana Trattamento Alcolismo & Sue Complican, SITAC, Rome, Italy

[3] Sapienza Univ Rome, Inst Biochem & Cell Biol IBBC CNR, Dept Sensory Organs, Rome, Italy

[4] Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, Rome, Italy

[5] Ist Super Sanita, Natl Ctr Addict & Doping, Rome, Italy

[6] Sapienza Univ Rome, Dept Expt Med, Rome, Italy

[7] Univ LAquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy

[8] ASUR Marche, AV4, Ancona, Italy

[9] ASL Rieti, UOC Patol Dipendenza, Rieti, Italy

来源：

RIVISTA DI PSICHIATRIA | 2024年 / 59卷 / 02期

关键词：

Alcohol; EtG; FAEE; FASD; infants; meco-; nium; neurodevelopment; ACID ETHYL-ESTERS; SPECTRUM DISORDER; GRIFFITHS SCALES; MATERNAL HAIR; COGNITIVE-DEVELOPMENT; YOUNG-CHILDREN; FETAL EXPOSURE; PREVALENCE; PREGNANCY; ETHYLGLUCURONIDE;

D O I：

暂无

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Introduction. Prenatal alcohol exposure causes a variety of impairments to the fetus called Fetal Alcohol Spectrum Disorders (FASD). Since it is very difficult to identify women that consume alcohol during pregnancy, different methods have been studied to evaluate alcohol exposure. Ethyl Glucuronide (EtG) and Fatty Acid Ethyl Esters (FAEEs) are commonly used to measure alcohol consumption in individuals at -risk for alcohol abuse, including pregnant women. Materials and methods. We conducted a study of two cohorts of 1.5 year -old infants (of mothers without a history of alcohol abuse) with or without meconium samples positive to both EtG and FAEEs and we evaluated their cognitive -behavioral development by the Griffiths Mental Developmental Scale (GMDS) method. Our protocol included 8 infants with meconium positive to alcohol metabolites (EtG and FAEEs) and 7 with meconium negative to alcohol metabolites. Results. None of the 8 alcohol metabolites positive meconium infants exhibited distinctive facial features and growth retardation of severe FASD, showing that other factors may contribute to the FASD onset but elevations in EtG and FAEEs in the meconium were significantly associated with disrupted neurodevelopment and adaptive functions within the first year and a half of life. Indeed, we found out that infants with meconium positive for both EtG and FAEEs, although without displaying any FASD morphological features, had a delay in the fine regulation of their own locomotory capabilities. Conclusions. Further analyses and larger studies are needed to estimate the right link between prenatal alcohol exposure and the different range of disorders connected but this study provides an additional step in the field of FASD in order to suggest early treatments for at -risk newborns and infants.

引用

页码：52 / 59

页数：8

共 77 条

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