Long-term endocrine sequelae after hematopoietic stem cell transplantation in children and adolescents

被引:0
作者
Hwang, Soojin [1 ]
Lee, Yena [2 ]
Yoon, Ji-Hee [1 ]
Kim, Ja Hye [1 ]
Kim, Hyery [1 ]
Koh, Kyung-Nam [1 ]
Im, Ho Joon [1 ]
Yoo, Han-Wook [3 ]
Choi, Jin-Ho [1 ,4 ]
机构
[1] Univ Ulsan, Asan Med Ctr, Dept Pediat, Childrens Hosp,Coll Med, Seoul, South Korea
[2] Hallym Univ, Coll Med, Dept Pediat, Sacred Heart Hosp, Anyang, South Korea
[3] CHA Univ, CHA Bundang Med Ctr, Dept Pediat, Seongnam, South Korea
[4] Univ Ulsan, Asan Med Ctr, Dept Pediat, Coll Med, 88 Olymp Ro 43 gil, Seoul 05505, South Korea
基金
新加坡国家研究基金会;
关键词
Children; Endocrine complication; Hematopoietic stem cell transplantation; BONE-MARROW-TRANSPLANTATION; CHILDHOOD-CANCER; DIABETES-MELLITUS; KOREAN CHILDREN; SURVIVORS; HEALTH; COMPLICATIONS; DISORDERS; DENSITY;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose: As the survival rate from pediatric cancers has increased significantly with advances in treatment modalities, long-term endocrine complications have also risen. This study investigated the frequencies and risks of endocrine sequelae in childhood cancer survivors who received hematopoietic stem cell transplantation (HSCT). Methods: This study included 200 pediatric patients who underwent HSCT. Clinical and endocrinological findings were collected retrospectively. The median follow-up duration after HSCT was 14 years. Results: Endocrine complications occurred in 135 patients (67.5%). Children who underwent HSCT at pubertal age (n=100) were at higher risk of endocrine complications than those who received it at prepubertal age (79% vs. 56%, P =0.001). The most common complication was hypogonadism (40%), followed by dyslipidemia (22%). Short stature and diabetes mellitus were more prevalent in the prepubertal group, whereas hypogonadism and osteoporosis were more common in the pubertal group. Being female, pubertal age at HSCT, and glucocorticoid use were predictors of an increased risk for any complication. Radiation exposure increased the risk of short stature and hypothyroidism. Hypogonadism was significantly associated with being female, pubertal age at HSCT, and highdose radiation. Pubertal age at HSCT also increased the risks of osteoporosis and dyslipidemia. Conclusion: This study demonstrates that long-term endocrine complications are common after HSCT in children and adolescents. Age at HSCT is a critical factor for endocrine complications after HSCT. These findings suggest that surveillance strategies for endocrine complications in childhood cancer survivors should be specified according to age at HSCT.
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页数:10
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