One-Pot Tandem/Spirocyclization Reaction: Synthesis of Spiro[pyridine-thiazolidine] Ring Derivatives

被引：2
作者：
Lin, Yuqun [1 ]
Shi, Jianyi [1 ]
Wu, Haoxian [1 ]
Hou, Ying [1 ]
Jiang, Shaohua [1 ]
Lo, Tsz Woon Benedict [2 ]
Zhu, Zhongzhi [1 ]
Luan, Tiangang [1 ,3 ]
Chen, Xiuwen [1 ]
机构：
[1] Wuyi Univ, Sch Environm & Chem Engn, Jiangmen Key Lab Synthet Chem & Cleaner Prod, Jiangmen 529020, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong 99077, Peoples R China
[3] Jieyang Ctr, Guangdong Lab Chem & Fine Chem Ind, Jieyang 515200, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 16期
基金：
中国国家自然科学基金;
关键词：
SPIROCYCLIC SCAFFOLDS; CONSTRUCTION;
D O I：
10.1021/acs.joc.4c01575
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot, three-component approach was devised to synthesize spiro[pyridine-thiazolidine] ring skeletons using thiazole salts, aldehydes, and enaminones. This method allows the assembly of structurally diverse spiroazepines through [3 + 1 + 2] tandem/spirocyclization reactions. This spirocyclization reaction offers several advantages, including transition metal-free conditions, high chemoselectivity, and the ability to construct structurally novel polycyclic compounds.
引用
收藏
页码：11727 / 11738
页数：12
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