One-Pot Tandem/Spirocyclization Reaction: Synthesis of Spiro[pyridine-thiazolidine] Ring Derivatives

被引：2

作者：

Lin, Yuqun ^{[1
]}

Shi, Jianyi ^{[1
]}

Wu, Haoxian ^{[1
]}

Hou, Ying ^{[1
]}

Jiang, Shaohua ^{[1
]}

Lo, Tsz Woon Benedict ^{[2
]}

Zhu, Zhongzhi ^{[1
]}

Luan, Tiangang ^{[1
,3
]}

Chen, Xiuwen ^{[1
]}

机构：

[1] Wuyi Univ, Sch Environm & Chem Engn, Jiangmen Key Lab Synthet Chem & Cleaner Prod, Jiangmen 529020, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong 99077, Peoples R China

[3] Jieyang Ctr, Guangdong Lab Chem & Fine Chem Ind, Jieyang 515200, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 16期

基金：

中国国家自然科学基金;

关键词：

SPIROCYCLIC SCAFFOLDS; CONSTRUCTION;

D O I：

10.1021/acs.joc.4c01575

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot, three-component approach was devised to synthesize spiro[pyridine-thiazolidine] ring skeletons using thiazole salts, aldehydes, and enaminones. This method allows the assembly of structurally diverse spiroazepines through [3 + 1 + 2] tandem/spirocyclization reactions. This spirocyclization reaction offers several advantages, including transition metal-free conditions, high chemoselectivity, and the ability to construct structurally novel polycyclic compounds.

引用

页码：11727 / 11738

页数：12

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