Advances in diagnosis and management of cancer of the esophagus

被引:72
作者
Deboever, Nathaniel [1 ]
Jones, Christopher M. [2 ,3 ]
Yamashita, Kohei [4 ]
Ajani, Jaffer A. [4 ]
Hofstetter, Wayne L. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA
[2] Univ Cambridge, Early Canc Inst, Dept Oncol, Cambridge, England
[3] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge, England
[4] MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA
来源
BMJ-BRITISH MEDICAL JOURNAL | 2024年 / 385卷
关键词
SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; OLIGOMETASTATIC ESOPHAGOGASTRIC CANCER; GASTROESOPHAGEAL JUNCTION CANCER; EXTENDED TRANSTHORACIC RESECTION; COMBINED-MODALITY THERAPY; PHASE-III TRIAL; BARRETTS-ESOPHAGUS; OPEN-LABEL; PERIOPERATIVE CHEMOTHERAPY;
D O I
10.1136/bmj-2023-074962
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Esophageal cancer is the seventh most common malignancy worldwide, with over 470 000 new cases diagnosed each year. Two distinct histological subtypes predominate, and should be considered biologically separate disease entities.1 These subtypes are esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Outcomes remain poor regardless of subtype, with most patients presenting with late stage disease.2 Novel strategies to improve early detection of the respective precursor lesions, squamous dysplasia, and Barrett's esophagus offer the potential to improve outcomes. The introduction of a limited number of biologic agents, as well as immune checkpoint inhibitors, is resulting in improvements in the systemic treatment of locally advanced and metastatic esophageal cancer. These developments, coupled with improvements in minimally invasive surgical and endoscopic treatment approaches, as well as adaptive and precision radiotherapy technologies, offer the potential to improve outcomes still further. This review summarizes the latest advances in the diagnosis and management of esophageal cancer, and the developments in understanding of the biology of this disease.
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页数:22
相关论文
共 274 条
[131]   Single-cell transcriptomics provides insights into the origin and microenvironment of human oesophageal high-grade intraepithelial neoplasia [J].
Liao, Guobin ;
Dai, Nan ;
Xiong, Tiantian ;
Wang, Liang ;
Diao, Xinwei ;
Xu, Zhizhen ;
Ni, Yuanli ;
Chen, Dingrong ;
Jiang, Airui ;
Lin, Hui ;
Dai, Shuangshuang ;
Bai, Jianying .
CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 12 (05)
[132]   Genomic and molecular characterization of esophageal squamous cell carcinoma [J].
Lin, De-Chen ;
Hao, Jia-Jie ;
Nagata, Yasunobu ;
Xu, Liang ;
Shang, Li ;
Meng, Xuan ;
Sato, Yusuke ;
Okuno, Yusuke ;
Varela, Ana Maria ;
Ding, Ling-Wen ;
Garg, Manoj ;
Liu, Li-Zhen ;
Yang, Henry ;
Yin, Dong ;
Shi, Zhi-Zhou ;
Jiang, Yan-Yi ;
Gu, Wen-Yue ;
Gong, Ting ;
Zhang, Yu ;
Xu, Xin ;
Kalid, Ori ;
Shacham, Sharon ;
Ogawa, Seishi ;
Wang, Ming-Rong ;
Koeffler, H. Phillip .
NATURE GENETICS, 2014, 46 (05) :467-473
[133]   Cancer vaccines: the next immunotherapy frontier [J].
Lin, Matthew J. ;
Svensson-Arvelund, Judit ;
Lubitz, Gabrielle S. ;
Marabelle, Aurelien ;
Melero, Ignacio ;
Brown, Brian D. ;
Brody, Joshua D. .
NATURE CANCER, 2022, 3 (08) :911-926
[134]   Randomized Phase IIB Trial of Proton Beam Therapy Versus Intensity-Modulated Radiation Therapy for Locally Advanced Esophageal Cancer [J].
Lin, Steven H. ;
Hobbs, Brian P. ;
Verma, Vivek ;
Tidwell, Rebecca S. ;
Smith, Grace L. ;
Lei, Xiudong ;
Corsini, Erin M. ;
Mok, Isabel ;
Wei, Xiong ;
Yao, Luyang ;
Wang, Xin ;
Komaki, Ritsuko U. ;
Chang, Joe Y. ;
Chun, Stephen G. ;
Jeter, Melenda D. ;
Swisher, Stephen G. ;
Ajani, Jaffer A. ;
Blum-Murphy, Mariela ;
Vaporciyan, Ara A. ;
Mehran, Reza J. ;
Koong, Albert C. ;
Gandhi, Saumil J. ;
Hofstetter, Wayne L. ;
Hong, Theodore S. ;
Delaney, Thomas F. ;
Liao, Zhongxing ;
Mohan, Radhe .
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (14) :1569-+
[135]   Proton Beam Therapy and Concurrent Chemotherapy for Esophageal Cancer [J].
Lin, Steven H. ;
Komaki, Ritsuko ;
Liao, Zhongxing ;
Wei, Caimiao ;
Myles, Bevan ;
Guo, Xiaomao ;
Palmer, Matthew ;
Mohan, Radhe ;
Swisher, Stephen G. ;
Hofstetter, Wayne L. ;
Ajani, Jaffer A. ;
Cox, James D. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 83 (03) :E345-E351
[136]   The Microenvironment in Barrett's Esophagus Tissue Is Characterized by High FOXP3 and RALDH2 Levels [J].
Lind, Alexandra ;
Siersema, Peter D. ;
Kusters, Johannes G. ;
Konijn, Tanja ;
Mebius, Reina E. ;
Koenderman, Leo .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[137]   The Immune Cell Composition in Barrett's Metaplastic Tissue Resembles That in Normal Duodenal Tissue [J].
Lind, Alexandra ;
Siersema, Peter D. ;
Kusters, Johannes G. ;
Van der Linden, Jan A. M. ;
Knol, Edward F. ;
Koenderman, Leo .
PLOS ONE, 2012, 7 (04)
[138]  
Lindor N.M., 2008, J Natl Cancer Inst Monogr, V38, P1, DOI [DOI 10.1093/JNCIMONOGRAPHS/LGN001, 10.1093/jncimonographs/lgn001]
[139]   Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA [J].
Liu, M. C. ;
Oxnard, G. R. ;
Klein, E. A. ;
Swanton, C. ;
Seiden, M., V .
ANNALS OF ONCOLOGY, 2020, 31 (06) :745-759
[140]   Systemic therapy with or without local intervention for oligometastatic oesophageal squamous cell carcinoma (ESO-Shanghai 13): an open-label, randomised, phase 2 trial [J].
Liu, Qi ;
Chen, Junqiang ;
Lin, Yu ;
Ye, Jinjun ;
Shen, Wenbin ;
Luo, Honglei ;
Li, Baosheng ;
Huang, Wei ;
Wei, Shihong ;
Song, Jibin ;
Wang, Yaohui ;
Yang, Huanjun ;
Lai, Songtao ;
Zhu, Hongcheng ;
Ai, Dashan ;
Chen, Yun ;
Deng, Jiaying ;
Hao, Shengnan ;
Zhao, Kuaile .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2024, 9 (01) :45-55