Advances in diagnosis and management of cancer of the esophagus

被引：72

作者：

Deboever, Nathaniel ^{[1
]}

Jones, Christopher M. ^{[2
,3
]}

Yamashita, Kohei ^{[4
]}

Ajani, Jaffer A. ^{[4
]}

Hofstetter, Wayne L. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Houston, TX 77030 USA

[2] Univ Cambridge, Early Canc Inst, Dept Oncol, Cambridge, England

[3] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge, England

[4] MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX USA

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2024年 / 385卷

关键词：

SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; OLIGOMETASTATIC ESOPHAGOGASTRIC CANCER; GASTROESOPHAGEAL JUNCTION CANCER; EXTENDED TRANSTHORACIC RESECTION; COMBINED-MODALITY THERAPY; PHASE-III TRIAL; BARRETTS-ESOPHAGUS; OPEN-LABEL; PERIOPERATIVE CHEMOTHERAPY;

D O I：

10.1136/bmj-2023-074962

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Esophageal cancer is the seventh most common malignancy worldwide, with over 470 000 new cases diagnosed each year. Two distinct histological subtypes predominate, and should be considered biologically separate disease entities.1 These subtypes are esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Outcomes remain poor regardless of subtype, with most patients presenting with late stage disease.2 Novel strategies to improve early detection of the respective precursor lesions, squamous dysplasia, and Barrett's esophagus offer the potential to improve outcomes. The introduction of a limited number of biologic agents, as well as immune checkpoint inhibitors, is resulting in improvements in the systemic treatment of locally advanced and metastatic esophageal cancer. These developments, coupled with improvements in minimally invasive surgical and endoscopic treatment approaches, as well as adaptive and precision radiotherapy technologies, offer the potential to improve outcomes still further. This review summarizes the latest advances in the diagnosis and management of esophageal cancer, and the developments in understanding of the biology of this disease.

引用

页数：22

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