Evaluation of Posaconazole Serum Concentrations Achieved With Delayed-release Tablets and Oral Suspension in Patients Undergoing Intensive Chemotherapy for Acute Myeloid Leukemia and Myelodysplastic Syndrome

被引：2

作者：

Muehlberg, Leonora ^{[1
]}

Pabst, Thomas ^{[2
]}

Largiader, Carlo ^{[3
,4
]}

Aebi, Yolanda ^{[3
,4
]}

Hayoz, Michael ^{[3
,4
]}

Muehlethaler, Konrad ^{[5
]}

Zimmerli, Stefan ^{[1
]}

Hirzel, Cedric ^{[1
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Dept Infect Dis, Inselspital, Bern, Switzerland

[2] Bern Univ Hosp, Dept Med Oncol, Inselspital, Bern, Switzerland

[3] Bern Univ Hosp, Dept Clin Chem, Inselspital, Bern, Switzerland

[4] Univ Bern, Bern, Switzerland

[5] Univ Bern, Inst Infect Dis, Dept Clin Microbiol, Bern, Switzerland

来源：

OPEN FORUM INFECTIOUS DISEASES | 2024年 / 11卷 / 05期

关键词：

acute myeloid leukemia; intensive chemotherapy; myelodysplastic syndrome; posaconazole prophylaxis; PRIMARY ANTIFUNGAL PROPHYLAXIS; CLINICAL-EFFICACY; ALLOGENEIC BLOOD; FLUCONAZOLE; SAFETY; ITRACONAZOLE;

D O I：

10.1093/ofid/ofae263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Data on posaconazole serum levels of patients on prophylaxis with delayed-release tablets or oral suspension during intensive chemotherapy for acute myeloid leukemia and myelodysplastic syndrome are scarce. In this analysis, the proportion of patients with acute myeloid leukemia/myelodysplastic syndrome achieving posaconazole target concentrations with delayed-release tablets was higher than with oral suspension.

引用

页数：4

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