Cobalt-catalyze d re ductive alkynylation to construct C(sp)-C(sp3 ) and C(sp)-C(sp2 ) bonds

被引：15

作者：

Wan, Lei ^{[1
]}

Tong, Yizhou ^{[1
]}

Lu, Xi ^{[2
]}

Fu, Yao ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, CAS Key Lab Urban Pollutant Convers, Anhui Prov Key Lab Biomass Clean Energy,iChEM, Hefei 230026, Peoples R China

[2] Univ Sci & Technol China, Sch Chem & Mat Sci, Key Lab Precis & Intelligent Chem, Hefei 230026, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2024年 / 35卷 / 07期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

Cobalt; -catalysis; Cross-electrophile coupling; Carbon-carbon bond formation; Reductive alkynylation; Alkyne synthesis; SECONDARY ALKYL BROMIDES; CROSS-COUPLINGS; DECARBOXYLATIVE ALKYNYLATION; SONOGASHIRA REACTIONS; CARBOXYLIC-ACIDS; REACTIVITY; HALIDES;

D O I：

10.1016/j.cclet.2023.109283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon-carbon bonds. Herein, we report a general method, cobalt-catalyzed reductive alkynylation, to construct C(sp)-C(sp3 ) and C(sp)-C(sp2 ) bonds. This presented reaction has a broad substrate scope, enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl (pseudo)halides. This presented reaction is conducted under mild conditions, tolerating many functional groups, thus suitable for the modification and synthesis of biologically active molecules. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

引用

页数：6

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