Ferroptosis in the neurovascular unit after spinal cord injury

被引：1
作者：
Huang, Yushan [1 ]
Bai, Jinzhu [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Sch Rehabil, 10 Jiaomen North Rd, Beijing, Peoples R China
[2] Beijing Boai Hosp, Dept Spine & Spinal Cord Surg, 10 Jiaomen North Rd, Beijing, Peoples R China
[3] Capital Med Univ, Dept Orthoped, Beijing, Peoples R China
来源：
EXPERIMENTAL NEUROLOGY | 2024年 / 381卷
关键词：
Spinal cord injury; Ferroptosis; Neurovascular unit; Secondary injury; CELL-DEATH; MICROGLIAL ACTIVATION; FUNCTIONAL RECOVERY; LIPID-PEROXIDATION; ENDOTHELIAL-CELLS; BRAIN-INJURY; INFLAMMATION; INHIBITION; EXPRESSION; BARRIER;
D O I：
10.1016/j.expneurol.2024.114943
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis and attenuate secondary spinal cord injury(SCI). This review focuses on the mechanisms of ferroptosis in NVU cells and NVU-targeted therapeutic strategies according to the stages of SCI, and analyzes possible future research directions.
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页数：11
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共 144 条
  • [1] Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration
    Abdalkader, Moataz
    Lampinen, Riikka
    Kanninen, Katja M.
    Malm, Tarja M.
    Liddell, Jeffrey R.
    [J]. FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [2] Traumatic Spinal Cord Injury-Repair and Regeneration
    Ahuja, Christopher S.
    Nori, Satoshi
    Tetreault, Lindsay
    Wilson, Jefferson
    Kwon, Brian
    Harrop, James
    Choi, David
    Fehlings, Michael G.
    [J]. NEUROSURGERY, 2017, 80 (03) : S9 - S22
  • [3] Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms
    Alizadeh, Arsalan
    Dyck, Scott Matthew
    Karimi-Abdolrezaee, Soheila
    [J]. FRONTIERS IN NEUROLOGY, 2019, 10
  • [4] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    Angeli, Jose Pedro Friedmann
    Schneider, Manuela
    Proneth, Bettina
    Tyurina, Yulia Y.
    Tyurin, Vladimir A.
    Hammond, Victoria J.
    Herbach, Nadja
    Aichler, Michaela
    Walch, Axel
    Eggenhofer, Elke
    Basavarajappa, Devaraj
    Radmark, Olof
    Kobayashi, Sho
    Seibt, Tobias
    Beck, Heike
    Neff, Frauke
    Esposito, Irene
    Wanke, Ruediger
    Foerster, Heidi
    Yefremova, Olena
    Heinrichmeyer, Marc
    Bornkamm, Georg W.
    Geissler, Edward K.
    Thomas, Stephen B.
    Stockwell, Brent R.
    O'Donnell, Valerie B.
    Kagan, Valerian E.
    Schick, Joel A.
    Conrad, Marcus
    [J]. NATURE CELL BIOLOGY, 2014, 16 (12) : 1180 - U120
  • [5] Glial and neuronal control of brain blood flow
    Attwell, David
    Buchan, Alastair M.
    Charpak, Serge
    Lauritzen, Martin
    MacVicar, Brian A.
    Newman, Eric A.
    [J]. NATURE, 2010, 468 (7321) : 232 - 243
  • [6] The Blood-Spinal Cord Barrier: Morphology and Clinical Implications
    Bartanusz, Viktor
    Jezova, Daniela
    Alajajian, Betty
    Digicaylioglu, Murat
    [J]. ANNALS OF NEUROLOGY, 2011, 70 (02) : 194 - 206
  • [7] Heme Degradation and Vascular Injury
    Belcher, John D.
    Beckman, Joan D.
    Balla, Gyorgy
    Balla, Jozsef
    Vercellotti, Gregory
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2010, 12 (02) : 233 - 248
  • [8] Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury
    Bellver-Landete, Victor
    Bretheau, Floriane
    Mailhot, Benoit
    Vallieres, Nicolas
    Lessard, Martine
    Janelle, Marie-Eve
    Vernoux, Nathalie
    Tremblay, Marie-Eve
    Fuehrmann, Tobias
    Shoichet, Molly S.
    Lacroix, Steve
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [9] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
    Bersuker, Kirill
    Hendricks, Joseph M.
    Li, Zhipeng
    Magtanong, Leslie
    Ford, Breanna
    Tang, Peter H.
    Roberts, Melissa A.
    Tong, Bingqi
    Maimone, Thomas J.
    Zoncu, Roberto
    Bassik, Michael C.
    Nomura, Daniel K.
    Dixon, Scott J.
    Olzmann, James A.
    [J]. NATURE, 2019, 575 (7784) : 688 - +
  • [10] Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
    Bisht, Kanchan
    Okojie, Kenneth A.
    Sharma, Kaushik
    Lentferink, Dennis H.
    Sun, Yu-Yo
    Chen, Hong-Ru
    Uweru, Joseph O.
    Amancherla, Saipranusha
    Calcuttawala, Zainab
    Campos-Salazar, Antony Brayan
    Corliss, Bruce
    Jabbour, Lara
    Benderoth, Jordan
    Friestad, Bria
    Mills, William A.
    Isakson, Brant E.
    Tremblay, Marie-Eve
    Kuan, Chia-Yi
    Eyo, Ukpong B.
    [J]. NATURE COMMUNICATIONS, 2021, 12 (01)
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