Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Preeclampsia-Induced Apoptosis of Placental Trophoblastic Cells Via Inhibiting the Mitochondrial Unfolded Protein Response

被引:0
作者
Zhao, Jing [1 ,2 ]
Yang, Yanan [3 ]
Qin, Jiayi [4 ]
Tao, Siyu [1 ]
Jiang, Chunmei [4 ]
Huang, Huixuan [4 ]
Wan, Qiunan [1 ]
Chen, Yuqi [4 ]
Xu, Shouzhu [3 ]
Qiao, Haifa [1 ,2 ]
机构
[1] Shaanxi Univ Chinese Med, Coll Acupuncture & Tuina, Xianyang 712046, Peoples R China
[2] Shaanxi Key Lab Acupuncture & Med, Xianyang 712046, Peoples R China
[3] Shaanxi Univ Chinese Med, Dept Publ Hlth, Xianyang 712046, Peoples R China
[4] Shaanxi Univ Chinese Med, Coll Med Technol, Xianyang 712046, Peoples R China
基金
中国国家自然科学基金;
关键词
Preeclampsia; Transcutaneous auricular vagus nerve stimulation; Acetylcholine; Reactive oxygen species; Mitochondrial unfolded protein response; Placental trophoblastic cells; VEIN ENDOTHELIAL-CELLS; ACETYLCHOLINE; MECHANISMS; PORE; UPR;
D O I
10.1007/s12264-024-01244-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Preeclampsia is a serious obstetric complication. Currently, there is a lack of effective preventive approaches for this disease. Recent studies have identified transcutaneous auricular vagus nerve stimulation (taVNS) as a potential novel non-pharmaceutical therapeutic modality for preeclampsia. In this study, we investigated whether taVNS inhibits apoptosis of placental trophoblastic cells through ROS-induced UPRmt. Our results showed that taVNS promoted the release of acetylcholine (ACh). ACh decreased the expression of UPRmt by inhibiting the formation of mitochondrial ROS (mtROS), presumably through M3AChR. This reduced the release of pro-apoptotic proteins (cleaved caspase-3, NF-kappa B-p65, and cytochrome C) and helped preserve the morphological and functional integrity of mitochondria, thus reducing the apoptosis of placental trophoblasts, improving placental function, and relieving preeclampsia. Our study unravels the potential pathophysiological mechanism of preeclampsia. In-depth characterization of the UPRmt is essential for developing more effective therapeutic strategies for preeclampsia targeting mitochondrial function.
引用
收藏
页码:1502 / 1518
页数:17
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