Artificial nonenzymatic antioxidant Prussian blue/KGM-BSA nanocomposite hydrogel dressing as ROS scavenging for diabetic wound healing

被引：15

作者：

Tang, Dong-Xu ^{[1
]}

Liu, Kun ^{[1
]}

Yang, Jin-Yu ^{[1
,2
]}

Wang, Zhi-Jun ^{[1
]}

Fu, Li -Li ^{[1
]}

Yang, Xiao-Jie ^{[1
]}

Li, Yue-Sheng ^{[1
]}

Huang, Bin ^{[3
]}

Liu, Yi ^{[4
]}

机构：

[1] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Hubei Key Lab Radiat Chem & Funct Mat, Xianning 437100, Hubei, Peoples R China

[2] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Hubei, Peoples R China

[3] Hubei Univ Sci & Technol, Xianing Med Coll, Sch Stomatol & Ophthalmol, Dept Stomatol, Xianning 437100, Peoples R China

[4] Tiangong Univ, Coll Chem Engn & Technol, Tianjin 300387, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 266卷

关键词：

Prussian blue; ROS scavenging; Hydrogel dressing; Konjac glucomannan; Diabetic rats; NANOPARTICLES;

D O I：

10.1016/j.ijbiomac.2024.131106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The process of diabetic wound healing was influenced by the excessive proliferation of reactive oxygen species (ROS). Therefore, in the process of healing diabetic wounds, it was crucial to removing ROS. This study designed composited nanoparticles: KBP, consisted by Konjac glucomannan, bovine serum albumin, and Prussian blue. Then they were embedded in Konjac glucomannan and hydroxypropyl trimethylammonium chloride chitosan composite hydrogel (KH), The KBP@KH hydrogel finally achieved excellent efficacy in diabetic wound healing. The in vitro and in vivo experiments demonstrated that KPB nanoparticles exhibited favorable ROS scavenging capability and biosafety. The KBP@KH hydrogel not only effectively eliminated ROS from diabetic wounds, but also exhibited excellent wound adaptability. The KBP@KH hydrogel facilitated angiogenesis and suppressed the production of inflammatory factors. Overall, the KBP@KH hydrogel dressing was characterized by its userfriendly nature, safety, and high efficiency.

引用

页数：14