Is the enteric nervous system a lost piece of the gut-kidney axis puzzle linked to chronic kidney disease?

被引：2

作者：

Almeida, Patricia Pereira ^{[1
]}

Brito, Michele Lima ^{[1
]}

Thomasi, Beatriz ^{[2
]}

Mafra, Denise ^{[3
]}

Fouque, Denis ^{[4
]}

Knauf, Claude ^{[5
]}

Tavares-Gomes, Ana Lucia ^{[6
]}

Stockler-Pinto, Milena Barcza ^{[1
,5
]}

机构：

[1] Fluminense Fed Univ UFF, Pathol Post Grad Program, Niteroi, RJ, Brazil

[2] Michigan State Univ MSU, Dept Physiol, Neurosci Program, E Lansing, MI USA

[3] Fed Univ Rio de Janeiro UFRJ, Grad Program Biol Sci Physiol, Rio De Janeiro, Brazil

[4] Univ Lyon, INSERM 1060, CENS, Ctr Hop Lyon Sud,Dept Nephrol, Lyon, France

[5] Univ Toulouse III Paul Sabatier Toulouse, INSERM U1220 Inst Rech Sante Digest, CHU Purpan, Toulouse, France

[6] Fluminense Fed Univ UFF, Neurosci Post Grad Program, Niteroi, RJ, Brazil

来源：

LIFE SCIENCES | 2024年 / 351卷

关键词：

Chronic kidney disease; Enteric neurons; Enteric glia; Dysmotility; Inflammation; MYENTERIC AH NEURONS; GLIAL-CELLS; GASTROINTESTINAL MOTILITY; INTESTINAL INFLAMMATION; PHENOTYPIC PLASTICITY; ENHANCED EXCITABILITY; GASTRIC-MOTILITY; COLONIC TRANSIT; RENAL-FAILURE; MICROBIOTA;

D O I：

10.1016/j.lfs.2024.122793

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The enteric nervous system (ENS) regulates numerous functional and immunological attributes of the gastrointestinal tract. Alterations in ENS cell function have been linked to intestinal outcomes in various metabolic, intestinal, and neurological disorders. Chronic kidney disease (CKD) is associated with a challenging intestinal environment due to gut dysbiosis, which further affects patient quality of life. Although the gut-related repercussions of CKD have been thoroughly investigated, the involvement of the ENS in this puzzle remains unclear. ENS cell dysfunction, such as glial reactivity and alterations in cholinergic signaling in the small intestine and colon, in CKD are associated with a wide range of intestinal pathways and responses in affected patients. This review discusses how the ENS is affected in CKD and how it is involved in gut-related outcomes, including intestinal permeability, inflammation, oxidative stress, and dysmotility.

引用

页数：12

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