Anti-Neuron-Derived Neurotrophic Factor Antibodies in Secondary Membranous Nephropathy Caused by Syphilis: A Case Report

被引：4

作者：

Honda, Daisuke ^{[1
]}

Okunaga, Issei ^{[1
]}

Omote, Daichi ^{[1
]}

Inoue, Hiroko ^{[1
]}

Yamasaki, Kaho ^{[1
]}

Wakabayashi, Hanae ^{[1
]}

Suzuki, Michiko ^{[1
]}

Aizawa, Masashi ^{[1
]}

Tomita, Shigeki ^{[2
]}

Ikeda, Jun-ichiro ^{[3
]}

Asanuma, Katsuhiko ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Nephrol, 1-8-1 Inohana,Chuo Ku, Chiba, Chiba 2608677, Japan

[2] Juntendo Univ, Dept Pathol, Urayasu Hosp, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Diagnost Pathol, Chiba, Japan

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2024年 / 84卷 / 02期

基金：

日本学术振兴会;

关键词：

Anti-neuron–derived neurotrophic factor antibody; Immune complex; Nephrotic syndrome; Neuron-derived neurotrophic factor; Secondary membranous nephropathy; Syphilis;

D O I：

10.1053/j.ajkd.2024.02.007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We present the case of a 61-year-old man who developed nephrotic syndrome as a result of syphilis- associated secondary membranous nephropathy (MN). The patient showed nephrotic syndrome remission following antibiotic treatment for syphilis alone. Pathologically, the target antigen of immune complexes accumulated on glomerular basement membranes (GBM) in secondary MN caused by syphilis has been reported to be neuron-derived neurotrophic factor (NDNF). His renal histopathology was consistent with secondary MN caused by syphilis, with a full-house pattern on immunofluores- fl uores- cence microscopy, in addition to NDNF deposits that colocalized with IgG deposits granularly on the GBM. However, to date, there is no serological evidence for the involvement of NDNF in the GBM. In the present study, we found that anti-NDNF autoantibodies in the acute-phase serum disappeared in the convalescent-phase serum of a patient who recovered from syphilis and nephrotic syndrome after antibiotic therapy alone. This result supports the hypothesis that treatment of syphilis with antibiotics suppresses NDNF's ' s antigenicity. In summary, we found new serological evidence emphasizing that NDNF is an etiological antigen in secondary MN caused by syphilis.

引用

页码：250 / 254

页数：5

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