CLINICAL EFFICACY OF PHOTODYNAMIC THERAPY IN MANAGEMENT OF ORAL POTENTIALLY MALIGNANT DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS

被引:3
|
作者
Peralta-mamani, Mariela [1 ]
Silva, Bruna machado da [2 ]
Honorio, Heitor marques [2 ]
Rubira-bullen, Izabel regina fischer [1 ]
Hanna, Reem [3 ,4 ,5 ]
Silva, Paulo sergio santos da [1 ]
机构
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Bauru, SP, Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, SP, Brazil
[3] Univ Genoa, Dept Surg Sci & Integrated Diagnost, Genoa, Italy
[4] UCL Eastman Dent Inst, Fac Med Sci, Dept Restorat Dent Sci, London, England
[5] Kings Coll Hosp NHS Fdn Trust, Dept Oral Surg, London, England
关键词
Oral potentially malignant disorders; Photodynamic therapy; Lesion remission; Photosensitizers; Clinical outcomes; Light therapy; TOPICAL 5-AMINOLEVULINIC ACID; LIGHT-EMITTING DIODE; VERRUCOUS HYPERPLASIA; ACTINIC CHEILITIS; EPITHELIAL DYSPLASIA; LASER; PDT; LEUKOPLAKIA; BACTERIOCHLORINS; STRESS;
D O I
10.1016/j.jebdp.2023.101899
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objectives Despite phototherapy (in the form of photodynamic therapy (PDT)-mediated oxidative stress) being utilized in the management of oral potentially malignant disorders (OPMDs), the evidence of certainty remains unclear. Hence, this systematic review and meta-analysis (PROSPERO # CRD42021218748) is aimed to evaluate the clinical efficacy of PDT-induced oxidative stress in OPMDs Methods PubMed, Embase, Web of Science, Scopus, and Cochrane Library databases were searched without restriction of language or year of publication. In addition, gray literature was searched and a manual search was performed. Two independent reviewers screened all the studies, assessing data extraction, risk of bias and certainty of evidence. A narrative synthesis was carried out. For the meta-analysis, random effects were considered to determine the prevalence of a total and a partial remission (PR) of oral potentially malignant disorders (OPMDs). The certainty of evidence was explored using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. Results Twenty-three studies were included in the qualitative and quantitative syntheses. A total of 880 patients were included (564 males; 218 females) with an age range between 24 and 89-years-old. The results showed the prevalence of the total and partial remissions respectively for the following OPMLs: actinic cheilitis (AC): 69.9% and 2.4%; oral leukoplakia (OL): 44% and 36.9%; oral verrucous hyperplasia (OVH): 98.5%; oral erythroleukoplakia (OEL): 92.1% and 7.9%. The prevalence of no remission of OL was 18.8%. Conclusions PDT demonstrated significant results in clinical remission of OPMDs and most of the eligible studies have shown a total or a partial remission of the included lesions, but at a low or a very low certainty of evidence. Hence, further clinical studies with robust methodology are warranted to offer further validated data. Also, further evidence is required to understand further the mechanism of PDT-induced oxidative stress.
引用
收藏
页数:25
相关论文
共 50 条
  • [11] Human papillomavirus prevalence in oral potentially malignant disorders: Systematic review and meta-analysis
    de la Cour, Cecilie D.
    Sperling, Cecilie D.
    Belmonte, Federica
    Syrjanen, Stina
    Kjaer, Susanne K.
    ORAL DISEASES, 2021, 27 (03) : 431 - 438
  • [12] Salivary LDH in oral cancer and potentially malignant disorders: A systematic review and meta-analysis
    Iglesias-Velazquez, Oscar
    Lopez-Pintor, Rosa Maria
    Gonzalez-Serrano, Jose
    Casanas, Elisabeth
    Torres, Jesus
    Hernandez, Gonzalo
    ORAL DISEASES, 2022, 28 (01) : 44 - 56
  • [13] Targeted Therapy for the Management of Oral Potentially Malignant Disorders: A Systematic Review
    Schuch, Lauren Frenzel
    Girardi, Fabio Muradas
    Kirschnick, Laura Borges
    Chaves, Aline Lauda Freitas
    Kowalski, Luiz Paulo
    Bologna-Molina, Ronell
    Junior, William Nassib William
    Martins, Manoela Domingues
    Santos-Silva, Alan Roger
    ORAL DISEASES, 2025,
  • [14] Efficacy of photodynamic therapy in the treatment of oral candidiasis: a systematic review and meta-analysis
    Hu, Qiaoyu
    Li, Ting
    Yang, Jiadi
    Peng, Yanhui
    Liu, Qing
    Liu, Na
    BMC ORAL HEALTH, 2023, 23 (01):
  • [15] Clinical efficacy of photodynamic therapy of oral potentially malignant disorder
    Jing, Yin
    Shu, Rong
    Wu, Tingting
    Liu, Dongqi
    Luo, Xiao
    Sun, Jun
    Chen, Fangchun
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2024, 46
  • [16] Salivary metabolomics in oral potentially malignant disorders and oral cancer patients—a systematic review with meta-analysis
    Nur Syahirah Binti Mohd Nazar
    Anand Ramanathan
    Wan Maria Nabillah Ghani
    Faezah Binti Rokhani
    Pulikkotil Shaju Jacob
    Nurul Elma Binti Sabri
    Mohd Sukri Hassan
    Kathreena Kadir
    Lalli Dharmarajan
    Clinical Oral Investigations, 28
  • [17] Photodynamic therapy: a review and its prospective role in the management of oral potentially malignant disorders
    Saini, R.
    Poh, C. F.
    ORAL DISEASES, 2013, 19 (05) : 440 - 451
  • [18] Photodynamic therapy for oral potentially malignant disorders
    Jin, Xin
    Xu, Hao
    Deng, Jing
    Dan, Hongxia
    Ji, Ping
    Chen, Qianming
    Zeng, Xin
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2019, 28 : 146 - 152
  • [19] Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype
    Iocca, Oreste
    Sollecito, Thomas P.
    Alawi, Faizan
    Weinstein, Gregory S.
    Newman, Jason G.
    De Virgilio, Armando
    Di Maio, Pasquale
    Spriano, Giuseppe
    Pardinas Lopez, Simon
    Shanti, Rabie M.
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2020, 42 (03): : 539 - 555
  • [20] Smokeless Tobacco and Oral Potentially Malignant Disorders in South Asia: A Systematic Review and Meta-analysis
    Khan, Zohaib
    Khan, Sheraz
    Christianson, Lara
    Rehman, Sara
    Ekwunife, Obinna
    Samkange-Zeeb, Florence
    NICOTINE & TOBACCO RESEARCH, 2018, 20 (01) : 12 - 21