Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

被引：89
|
作者：
Passaro, Antonio [1 ]
Al Bakir, Maise [2 ,3 ]
Hamilton, Emily G. [4 ]
Diehn, Maximilian [4 ]
Andre, Fabrice [5 ,6 ]
Roy-Chowdhuri, Sinchita
Mountzios, Giannis [7 ]
Wistuba, Ignacio I. [8 ]
Swanton, Charles [2 ,3 ,9 ]
Peters, Solange [10 ]
机构：
[1] European Inst Oncol IRCCS, Div Thorac Oncol, Milan, Italy
[2] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England
[3] UCL, Canc Res UK Lung Canc Ctr Excellence, Canc Inst, London, England
[4] Stanford Univ, Stanford Canc Inst, Sch Med, Dept Radiat Oncol, Stanford, CA USA
[5] Paris Saclay Univ, Gustave Roussy Canc Ctr, Villejuif, France
[6] Univ Texas MD Anderson Canc Ctr, Dept Anat Pathol & Translat Mol Pathol, Houston, TX USA
[7] Henry Dunant Hosp Ctr, Dept Med Oncol 4, Athens, Greece
[8] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77054 USA
[9] Univ Coll London Hosp, Dept Oncol, London, England
[10] Ctr Hosp Univ Vaudois CHUV, Dept Oncol, Lausanne, Switzerland
来源：
CELL | 2024年 / 187卷 / 07期
关键词：
CELL LUNG-CANCER; CIRCULATING-TUMOR DNA; IMMUNE CHECKPOINT INHIBITORS; MOLECULAR RESIDUAL DISEASE; EXOME ANALYSIS REVEALS; KRAS MUTATION STATUS; PD-1; BLOCKADE; BREAST-CANCER; T-CELLS; MICROSATELLITE INSTABILITY;
D O I：
10.1016/j.cell.2024.02.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turning point and a new paradigm in cancer management, as biomarkers enable oncologists to tailor treatments based on the unique molecular profile of each patient's tumor. In this review, we discuss the scientific milestones of cancer biomarkers and explore future possibilities to improve the management of patients with solid tumors. This progress is primarily attributed to the biological characterization of cancers, advancements in testing methodologies, elucidation of the immune microenvironment, and the ability to profile circulating tumor fractions. Integrating these insights promises to continually advance the precision oncology field, fostering better patient outcomes.
引用
收藏
页码：1617 / 1635
页数：19
相关论文
共 50 条
  • [31] Personalized cancer treatment enters clinical trial
    不详
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (03) : 536 - 536
  • [32] Cancer Tsunami: Emerging Trends, Economic Burden, and Perioperative Implications
    McCormick P.J.
    Current Anesthesiology Reports, 2018, 8 (4) : 348 - 354
  • [33] MicroRNA as biomarkers in early detection and personalized treatment in ovarian cancer: Development of a personalized prevention consortium
    Fortner, Renee Turzanski
    langseth, HilDe
    CANCER RESEARCH, 2024, 84 (05)
  • [34] Novel molecules as the emerging trends in cancer treatment: an update
    Priyanka Sekar
    Raashmi Ravitchandirane
    Sofia Khanam
    Nethaji Muniraj
    Ananda Vayaravel Cassinadane
    Medical Oncology, 2022, 39
  • [35] Gastric Cancer Emerging Trends in Prevention, Diagnosis, and Treatment
    Norwood, Dalton A.
    Montalvan, Eleazar E.
    Dominguez, Ricardo L.
    Morgan, Douglas R.
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2022, 51 (03) : 501 - 518
  • [36] Novel molecules as the emerging trends in cancer treatment: an update
    Sekar, Priyanka
    Ravitchandirane, Raashmi
    Khanam, Sofia
    Muniraj, Nethaji
    Cassinadane, Ananda Vayaravel
    MEDICAL ONCOLOGY, 2022, 39 (02)
  • [37] Clinical utility of emerging liquid biomarkers in advanced prostate cancer
    Vandekerkhove, Gillian
    Chi, Kim N.
    Wyatt, Alexander W.
    CANCER GENETICS, 2018, 228 : 151 - 158
  • [38] Clinical utility of emerging biomarkers in prostate cancer liquid biopsies
    Boerrigter, Emmy
    Groen, Levi N.
    Van Erp, Nielka P.
    Verhaegh, Gerald W.
    Schalken, Jack A.
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2020, 20 (02) : 219 - 230
  • [39] Emerging Trends in Clinical Research: With Implications for Population Health and Health Policy
    Benjamin Chin-Yee
    Subramanian, S. V.
    Verma, Amol A.
    Laupacis, Andreas
    Razak, Fahad
    MILBANK QUARTERLY, 2018, 96 (02): : 369 - 401
  • [40] ADVANCING CANCER TREATMENT WITH DIAGNOSTIC ONCOLOGIC BIOMARKERS IN PERSONALIZED MEDICINE IN BULGARIA
    Krapcheva, Emilia M.
    Todorova, V
    Dacheva, A.
    Slavchev, G.
    Djambazov, S.
    VALUE IN HEALTH, 2024, 27 (12) : S112 - S112
12345