Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

被引：149

作者：

Passaro, Antonio ^{[1
]}

Al Bakir, Maise ^{[2
,3
]}

Hamilton, Emily G. ^{[4
]}

Diehn, Maximilian ^{[4
]}

Andre, Fabrice ^{[5
,6
]}

Roy-Chowdhuri, Sinchita

Mountzios, Giannis ^{[7
]}

Wistuba, Ignacio I. ^{[8
]}

Swanton, Charles ^{[2
,3
,9
]}

Peters, Solange ^{[10
]}

机构：

[1] European Inst Oncol IRCCS, Div Thorac Oncol, Milan, Italy

[2] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England

[3] UCL, Canc Res UK Lung Canc Ctr Excellence, Canc Inst, London, England

[4] Stanford Univ, Stanford Canc Inst, Sch Med, Dept Radiat Oncol, Stanford, CA USA

[5] Paris Saclay Univ, Gustave Roussy Canc Ctr, Villejuif, France

[6] Univ Texas MD Anderson Canc Ctr, Dept Anat Pathol & Translat Mol Pathol, Houston, TX USA

[7] Henry Dunant Hosp Ctr, Dept Med Oncol 4, Athens, Greece

[8] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77054 USA

[9] Univ Coll London Hosp, Dept Oncol, London, England

[10] Ctr Hosp Univ Vaudois CHUV, Dept Oncol, Lausanne, Switzerland

来源：

CELL | 2024年 / 187卷 / 07期

关键词：

CELL LUNG-CANCER; CIRCULATING-TUMOR DNA; IMMUNE CHECKPOINT INHIBITORS; MOLECULAR RESIDUAL DISEASE; EXOME ANALYSIS REVEALS; KRAS MUTATION STATUS; PD-1; BLOCKADE; BREAST-CANCER; T-CELLS; MICROSATELLITE INSTABILITY;

D O I：

10.1016/j.cell.2024.02.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The integration of cancer biomarkers into oncology has revolutionized cancer treatment, yielding remarkable advancements in cancer therapeutics and the prognosis of cancer patients. The development of personalized medicine represents a turning point and a new paradigm in cancer management, as biomarkers enable oncologists to tailor treatments based on the unique molecular profile of each patient's tumor. In this review, we discuss the scientific milestones of cancer biomarkers and explore future possibilities to improve the management of patients with solid tumors. This progress is primarily attributed to the biological characterization of cancers, advancements in testing methodologies, elucidation of the immune microenvironment, and the ability to profile circulating tumor fractions. Integrating these insights promises to continually advance the precision oncology field, fostering better patient outcomes.

引用

页码：1617 / 1635

页数：19

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