Subthalamic nucleus local field potential stability in patients with Parkinson's disease

被引：3

作者：

Fasano, Alfonso ^{[1
,2
,3
,4
]}

Mure, Hideo ^{[5
]}

Oyama, Genko ^{[6
]}

Murase, Nagako ^{[7
]}

Witt, Thomas ^{[8
]}

Higuchi, Yoshinori ^{[9
]}

Singer, Alexa ^{[10
]}

Sannelli, Claudia ^{[10
]}

Morelli, Nathan ^{[10
]}

机构：

[1] UHN, Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada

[2] Univ Toronto, Div Neurol, Toronto, ON, Canada

[3] Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada

[4] Ctr Adv Neurotechnol Innovat Applicat, Toronto, ON, Canada

[5] Kurashiki Heisei Hosp, Ctr Neuromodulat, Dept Neurosurg, Kurashiki, Japan

[6] Juntendo Univ, Fac Med, Dept Neurol, Tokyo, Japan

[7] Natl Hosp Org, Nara Med Ctr, Dept Neurol, Nara, Japan

[8] Indiana Univ, Med Ctr, Dept Neurosurg, Indianapolis, IN USA

[9] Chiba Univ Hosp, Grad Sch Med, Dept Neurol Surg, Chiba, Japan

[10] Medtronic PLC, Brain Modulat Business, Neuromodulat Operating Unit, Minneapolis, MN USA

来源：

NEUROBIOLOGY OF DISEASE | 2024年 / 199卷

关键词：

Local field potentials; Parkinson's disease; Deep brain stimulation; DEEP-BRAIN-STIMULATION; RECORDINGS; OSCILLATIONS; REST;

D O I：

10.1016/j.nbd.2024.106589

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Despite the large body of work on local field potentials (LFPs), a measure of oscillatory activity in patients with Parkinson's disease (PD), the longitudinal evolution of LFPs is less explored. Objective: To determine LFP fluctuations collected in clinical settings in patients with PD and STN deep brain stimulation (DBS). Methods: Twenty-two STN-DBS patients (age: 67.6 +/- 8.3 years; 9 females; disease duration: 10.3 +/- 4.5 years) completed bilateral LFP recordings over three visits in the OFF-stimulation setting. Peak and band power measures were calculated from each recording. Results: After bilateral LFP recordings, at least one peak was detected in 18 (81.8%), 20 (90.9%), and 22 (100%) patients at visit 1, 2, and 3, respectively. No significant differences were seen in primary peak amplitude (F = 2.91, p = 0.060) over time. Amplitude of the second largest peak (F = 5.49, p = 0.006) and low-beta (F = 6.89, p = 0.002), high-beta (F = 13.23, p < 0.001), and gamma (F = 12.71, p < 0.001) band power demonstrated a significant effect of time. Post hoc comparisons determined low-beta power (Visit 1 -Visit 2: t = 3.59, p = 0.002; Visit 1 -Visit 3: t = 2.61, p = 0.031), high-beta (Visit 1 -Visit 2: t = 4.64, p < 0.001; Visit 1 -Visit 3: t = 4.23, p < 0.001) and gamma band power (Visit 1 -Visit 2: t = 4.65, p < 0.001; Visit 1 -Visit 3: t = 4.00, p < 0.001) were significantly increased from visit 1 recordings to both follow-up visits. Conclusion: Our results provide substantial evidence that LFP can reliably be detected across multiple real-world clinical visits in patients with STN-DBS for PD. Moreover, it provides insights on the evolution of these LFPs.

引用

页数：8

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[1] Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes [J].