Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes in Overweight and Obese Pregnant Women: A Post-Hoc Analysis of the San Carlos Gestational Prevention Study

被引：4

作者：

Martin-O'Connor, Rocio ^{[1
]}

Ramos-Levi, Ana ^{[1
]}

Melero, Veronica ^{[1
]}

Arnoriaga-Rodriguez, Maria ^{[1
]}

Barabash, Ana ^{[1
,2
,3
]}

Valerio, Johanna ^{[1
]}

del Valle, Laura ^{[1
]}

de Miguel, Paz ^{[1
,2
]}

Diaz, Angel ^{[1
,2
]}

Familiar, Cristina ^{[1
]}

Moraga, Inmaculada ^{[1
]}

Duran, Alejandra ^{[1
,2
]}

Cuesta, Martin ^{[1
,3
]}

Torrejon, Maria Jose ^{[4
]}

Martinez-Novillo, Mercedes ^{[4
]}

Marcuello, Clara ^{[1
]}

Pazos, Mario ^{[1
]}

Rubio, Miguel A. ^{[1
,2
]}

Matin, Pilar Matia ^{[1
,2
]}

Calle-Pascual, Alfonso L. ^{[1
,2
,3
]}

机构：

[1] Hosp Clin Univ San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Endocrinol & Nutr Dept, Madrid 28040, Spain

[2] Univ Complutense Madrid, Fac Med, Med Dept 2, Madrid 28040, Spain

[3] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain

[4] Hosp Clin Univ San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Clin Lab Dept, Madrid 28040, Spain

来源：

NUTRIENTS | 2024年 / 16卷 / 14期

关键词：

obesity; overweight; metabolic syndrome; fasting blood glucose; Mediterranean diet; gestational diabetes; INSULIN-RESISTANCE; INFLAMMATION; MELLITUS; MARKERS; RISK;

D O I：

10.3390/nu16142206

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Obesity is a risk factor for the development of gestational diabetes mellitus (GDM). However, the most optimal type of nutritional intervention to prevent GDM in high-risk women is not clearly defined. This study investigates if nutritional treatment based on the Mediterranean diet (MedDiet) before the 12th gestational week (GW) in women at high risk due to a body mass index (BMI) >= 25 kg/m2 reduces the rate of GDM and metabolic syndrome (MetS) at 3 years postpartum. We performed a post-hoc analysis of the San Carlos Gestational Prevention Study. A total of 735 women with BMI >= 25 kg/m2 were evaluated between 2015 and 2018, with 246 in the standard diet control group (CG) and 489 in the MedDiet intervention group (IG). The rate of GDM was significantly lower in IG compared to CG (25.1% vs. 31.7%), relative risk (95% confidence interval), and 0.89 (0.78-0.99); p = 0.037. Postnatal follow-up was completed by 141 women in CG (57%) and 312 women in IG (64%). At 3 years postpartum, we observed a reduction in the rates of impaired fasting glucose (IFG) (0.51 (0.28-0.92); p = 0.019), obesity (0.51 (0.28-0.92); p = 0.041), waist circumference (WC) >= 89.5 cm (0.54 (0.31-0.94); p = 0.022), and MetS (0.56 (0.33-0.94); p = 0.003). MedDiet reduces the rate of GDM and postpartum MetS in women with BMI) >= 25 kg/m2, suggesting that its implementation should be routinely recommended from the first GWs.

引用

页数：15

共 45 条

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