Fourteen undescribed steroidal saponins from Solanum capsicoides leaves and their neuroprotective effects

被引：3

作者：

Liu, Yan ^{[1
]}

Li, Xin-Yuan ^{[1
]}

Wu, Jia-tong ^{[1
]}

Wang, Han ^{[1
]}

Meng, Xin ^{[1
]}

Pan, Juan ^{[1
]}

Guan, Wei ^{[1
]}

Algradi, Adnan Mohammed ^{[1
]}

Naseem, Anam ^{[1
]}

Kuang, Hai-Xue ^{[1
]}

Yang, Bing-You ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Key Lab Basic & Applicat Res Beiyao, Minist Educ, Harbin 150040, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 222卷

关键词：

Solanum capsicoides; Solanaceae; Steroidal saponins; PC-12; GLYCOSIDES;

D O I：

10.1016/j.phytochem.2024.114091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A total of 14 previously undescribed steroidal saponins named capsicsaponins A-N were isolated from the leaves of Solanum capsicoides, encompassing various types, including cholesterol derivatives and pseudospirostanol saponins. The structures of all compounds were determined through comprehensive analysis of spectroscopic data (1D NMR and 2D NMR), along with physicochemical analysis methods (acid hydrolysis, OR, and UV). Moreover, in the H2O2-induced pheochromocytoma cell line model, compounds 1-14 were screened for their neuroprotective effects on cells. The bioassay results demonstrated compounds 8-14 were able to revive cell viability compared to the positive control edaravone. The damage neuroprotection of the most active compound was further explored.

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页数：12

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