Cytokine levels in Type-2 Diabetes Mellitus (T2DM) Patients with Asymptomatic Bacteriuria (ASB) in Northern Andhra Pradesh

被引：0

作者：

Sagar, K. V. S. B. Vidya ^{[1
,2
]}

Jyotsna, P. Sarat ^{[3
]}

Sethumadhavan, K. ^{[1
]}

Bandaru, Narasinga Rao ^{[2
]}

机构：

[1] Vinayaka Missions Res Fdn VMRF DU, Aarupadai Veedu Med Coll & Hosp, Dept Microbiol, Pondicherry, Tamil Nadu, India

[2] Gayatri Vidya Parishad Inst Hlth Care & Med Techno, Dept Microbiol, Visakhapatnam, Andhra Pradesh, India

[3] Govt Med Coll, Dept Nephrol, Srikakulam, Andhra Pradesh, India

来源：

JOURNAL OF PURE AND APPLIED MICROBIOLOGY | 2024年 / 18卷 / 02期

关键词：

Diabetes Mellitus; Asymptomatic Bacteriuria; Cytokines; Inflammation; INSULIN-SECRETION; PATHOGENESIS; CELLS;

D O I：

10.22207/JPAM.18.2.45

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Diabetes is a systemic inflammatory condition. The modulation of cytokine levels caused by Asymptomatic Bacteriuria (ASB) infection can lead to altered inflammatory status in various tissues and may affect their homeostasis and function. We aim to estimate the cytokine (IL-6, TNF-alpha and IL-10) levels in serum of diabetic individuals with and without ASB to study their clinical significance. The current study evaluates the role of cytokines in inflammation caused due to ASB in T2DM patients. Increase in IL-6 and TNF-alpha levels may indicate renal tissue damage caused due to inflammation by ASB. Whereas increased IL-10 levels is a possible indicator of persistent infection with bacteria which may lead to diabetic renal disease.

引用

页码：1246 / 1252

页数：7

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