Role of mitophagy in pulmonary hypertension: Targeting the mechanism and pharmacological intervention

被引：1

作者：

Wan, Jia-Jing ^{[1
,2
,3
]}

Yi, Jian ^{[5
]}

Wang, Fei-Ying ^{[2
,3
]}

Li, Xia ^{[2
,3
]}

Zhang, Chao ^{[2
,3
]}

Song, Lan ^{[2
,3
]}

Dai, Ai-Guo ^{[2
,3
,4
]}

机构：

[1] Hunan Univ Chinese Med, Sch Integrated Chinese & Western Med, Changsha 410208, Hunan, Peoples R China

[2] Hunan Univ Chinese Med, Sch Med, Dept Resp Dis, Changsha 410208, Hunan, Peoples R China

[3] Hunan Prov Key Lab Vasc Biol & Translat Med, Changsha 410208, Hunan, Peoples R China

[4] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Resp Med, Changsha 410021, Hunan, Peoples R China

[5] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China

来源：

MITOCHONDRION | 2024年 / 78卷

基金：

中国国家自然科学基金;

关键词：

Mitophagy; Pulmonary hypertension; Mechanism; AUTOPHAGY; APOPTOSIS; FUNDC1; MITOCHONDRIA; INHIBITION; METABOLISM; BINDING; PARKIN;

D O I：

10.1016/j.mito.2024.101928

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitophagy, a crucial pathway in eukaryotic cells, selectively eliminates dysfunctional mitochondria, thereby maintaining cellular homeostasis via mitochondrial quality control. Pulmonary hypertension (PH) refers to a pathological condition where pulmonary arterial pressure is abnormally elevated due to various reasons, and the underlying pathogenesis remains elusive. This article examines the molecular mechanisms underlying mitophagy, emphasizing its role in PH and the progress in elucidating related molecular signaling pathways. Additionally, it highlights current drug regulatory pathways, aiming to provide novel insights into the prevention and treatment of pulmonary hypertension.

引用

页数：7

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