Shear Flow-Assembled Janus Membrane with Bifunctional Osteogenic and Antibacterial Effects for Guided Bone Regeneration

被引：0
|
作者：
Ma, Zequn [1 ,2 ]
Hu, Xiantong [3 ]
Li, Xiangming [4 ]
An, Qi [2 ]
Zhang, Yi [5 ]
Guo, Chunxian [1 ]
Zhao, Yantao [3 ]
Zhang, Yihe [2 ]
机构：
[1] Suzhou Univ Sci & Technol, Inst Mat Sci & Devices, Sch Mat Sci & Engn, Suzhou 215009, Jiangsu, Peoples R China
[2] China Univ Geosci, Sch Mat Sci & Technol, Beijing Key Lab Mat Utilizat Nonmet Minerals & Sol, Natl Lab Mineral Mat, Beijing 100083, Peoples R China
[3] Peoples Liberat Army Gen Hosp, Med Ctr 4, Beijing Engn Res Ctr Orthoped Implants, Dept Orthoped, Beijing 100048, Peoples R China
[4] Guangdong Univ Petrochem Technol, Sch Mat Sci & Technol, Dept Funct Mat, Maoming 525000, Peoples R China
[5] Suzhou Univ Sci & Technol, Sch Chem & Life Sci, Suzhou 215009, Jiangsu, Peoples R China
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2024年 / 10卷 / 06期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Janus membrane; shear flow-drivenassembly; guided bone regeneration; osteogenic differentiation; antibacterial effect; CHITOSAN;
D O I：
10.1021/acsbiomaterials.4c00420
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Guided bone regeneration (GBR) membranes that reside at the interface between the bone and soft tissues for bone repair attract increasing attention, but currently developed GBR membranes suffer from relatively poor osteogenic and antibacterial effects as well as limited mechanical property and biodegradability. We present here the design and fabrication of a bifunctional Janus GBR membrane based on a shear flow-driven layer by a layer self-assembly approach. The Janus GBR membrane comprises a calcium phosphate-collagen/polyethylene glycol (CaP@COL/PEG) layer and a chitosan/poly(acrylic acid) (CHI/PAA) layer on different sides of a collagen membrane to form a sandwich structure. The membrane exhibits good mechanical stability and tailored biodegradability. It is found that the CaP@COL/PEG layer and CHI/PAA layer contribute to the osteogenic differentiation and antibacterial function, respectively. In comparison with the control group, the Janus GBR membrane displays a 2.52-time and 1.84-time enhancement in respective volume and density of newly generated bone. The greatly improved bone repair ability of the Janus GBR membrane is further confirmed through histological analysis, and it has great potential for practical applications in bone tissue engineering.
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页码：3984 / 3993
页数：10
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