Clinical Characteristics and Prognosis of Biliary Atresia with Low Serum Matrix Metalloproteinase-7 Levels

被引:1
作者
Jiang, Jingying [1 ]
Yang, Yifan [1 ]
Ren, Xue [1 ]
Xu, Chen [1 ]
Ye, Chunjing [1 ]
Zhou, Jin [1 ]
Qian, Manning [1 ]
Wang, Shuxin [1 ]
Chen, Gong [1 ]
Dong, Rui [1 ]
Zheng, Shan [1 ]
机构
[1] Fudan Univ, Childrens Hosp, Dept Pediat Surg, Shanghai Key Lab Birth Defects, 399 Wan Yuan Rd, Shanghai 201102, Peoples R China
基金
中国国家自然科学基金;
关键词
Biliary atresia; Matrix metalloproteinase-7; Prognosis; LIVER;
D O I
10.1016/j.jpedsurg.2023.11.019
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose: Serum matrix metalloproteinase-7 (MMP-7) levels can precisely differentiate biliary atresia (BA) from non -BA cholestasis. However, serum MMP-7 levels of some BA patients were within normal range or slightly elevated. This study aimed to investigate the clinical characteristics and prognosis of biliary atresia with low serum MMP-7 levels. Method: This is a retrospective cohort study. Cases of BA from July 2020 to December 2022 were consecutively enrolled. They were divided into low-MMP-7 group (MMP-7 <= 25 ng/ml) and high-MMP-7 group (MMP-7 > 25 ng/ml) according to serum MMP-7 levels preoperatively. The perioperative clinical characteristics, the 3 -month and 6 -month jaundice clearance rate post -Kasai procedure, and the native liver survival were compared between the two groups. Results: A total of 329 cases were included in this study, 40 of which were divided into the low-MMP-7 group. Preoperative GGT and direct bilirubin levels in the low-MMP-7 group were signi ficantly lower than those in the high-MMP-7 group (258.6 U/L, interquartile range [IQR]: 160.4411.6 vs. 406.8 IU/L, IQR: 215,655.0, P = 0.0076; 103.8 m mol/L, IQR: 79.0,121.4 vs. 115.3 m mol/L, IQR: 94,138.8, P = 0.0071), while the gender, the day at surgery and preoperative ALT, AST, TBA, total bilirubin levels showed no signi ficant differences (P > 0.05). The 3 -month and 6 -month jaundice clearance rate post -Kasai procedure in the low-MMP-7 group were lower than those in the high-MMP-7 group (29.73% vs. 53.09%, P = 0.049; 32.14% vs. 54.73%, P = 0.023). The 1 -year native liver survival rate was 29.63% for the low-MMP-7 group and 53.02% for the high-MMP-7 group (P = 0.022). Conclusion: Preoperative clinical characteristics were similar between low-MMP-7 group and highMMP-7 group, while patients with low serum MMP-7 levels showed worse prognosis, indicating that this might be listed as a new clinical subtype of BA which could contribute to designing new treatment strategies for BA in the future.
引用
收藏
页码:648 / 652
页数:5
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