Antiarrhythmic and Anti-Inflammatory Effects of Sacubitril/Valsartan on Post-Myocardial Infarction Scar

被引:1
|
作者
Martinez-Falguera, Daina [3 ,4 ]
Aranyo, Julia [5 ,6 ]
Teis, Albert [5 ]
Ferrer-Curriu, Gemma [3 ]
Monguio-Tortajada, Marta [3 ,7 ]
Fadeuilhe, Edgar [5 ]
Rodriguez-Leor, Oriol [5 ,8 ]
Diaz-Guemes, Idoia [3 ]
Roura, Santiago [3 ,5 ,8 ,9 ]
Villuendas, Roger [5 ,8 ]
Sarrias, Axel [5 ]
Bazan, Victor [5 ]
Delgado, Victoria [5 ]
Bayes-Genis, Antoni [3 ,5 ,6 ,8 ]
Bisbal, Felipe [1 ,5 ,8 ]
Galvez-Monton, Carolina [2 ,3 ,5 ,8 ]
机构
[1] Germans Trias i Pujol Univ Hosp, Carretera Canyet S N, Badalona 08916, Spain
[2] Germans Trias i Pujol Res Inst, Cami Escoles S N, Badalona 08916, Spain
[3] Germans Trias i Pujol Res Inst, ICREC Res Program, Barcelona, Spain
[4] Univ Barcelona, Fac Med, Barcelona, Spain
[5] Germans Trias i Pujol Univ Hosp, Heart Inst iCOR, Barcelona, Spain
[6] Autonomous Univ Barcelona, Dept Med, Barcelona, Spain
[7] Univ Lausanne, Dept Immunobiol, Epalinges, Vaud, Switzerland
[8] Inst Salud Carlos III, CIBER Cardiovasc, Madrid, Spain
[9] Univ Vic Cent Univ Catalonia, Fac Med, Barcelona, Spain
来源
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY | 2024年 / 17卷 / 05期
关键词
arrhythmias; cardiac; fibrosis; inflammation; myocardial infarction; sacubitril; valsartan; MYOCARDIAL-INFARCTION; VENTRICULAR-ARRHYTHMIA; HEART-FAILURE; INHIBITION; RECEPTOR;
D O I
10.1161/CIRCEP.123.012517
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND:Sacubitril/valsartan (Sac/Val) is superior to angiotensin-converting enzyme inhibitors in reducing the risk of heart failure hospitalization and cardiovascular death, but its mechanistic data on myocardial scar after myocardial infarction (MI) are lacking. The objective of this work was to assess the effects of Sac/Val on inflammation, fibrosis, electrophysiological properties, and ventricular tachycardia inducibility in post-MI scar remodeling in swine.METHODS:After MI, 22 pigs were randomized to receive beta-blocker (BB; control, n=8) or BB+Sac/Val (Sac/Val, n=9). The systemic immune response was monitored. Cardiac magnetic resonance data were acquired at 2-day and 29-day post MI to assess ventricular remodeling. Programmed electrical stimulation and high-density mapping were performed at 30-day post MI to assess ventricular tachycardia inducibility. Myocardial samples were collected for histological analysis.RESULTS:Compared with BB, BB+Sac/Val reduced acute circulating leukocytes (P=0.009) and interleukin-12 levels (P=0.024) at 2-day post MI, decreased C-C chemokine receptor type 2 expression in monocytes (P=0.047) at 15-day post MI, and reduced scar mass (P=0.046) and border zone mass (P=0.043). It also lowered the number and mass of border zone corridors (P=0.009 and P=0.026, respectively), scar collagen I content (P=0.049), and collagen I/III ratio (P=0.040). Sac/Val reduced ventricular tachycardia inducibility (P=0.034) and the number of deceleration zones (P=0.016).CONCLUSIONS:After MI, compared with BB, BB+Sac/Val was associated with reduced acute systemic inflammatory markers, reduced total scar and border zone mass on late gadolinium-enhanced magnetic resonance imaging, and lower ventricular tachycardia inducibility.
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页数:12
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